Abstract
Remarkable progress has been made in image classification and segmentation, due to the recent study of deep convolutional neural networks (CNNs). To solve the similar problem of diagnostic lung nodule detection in low-dose computed tomography (CT) scans, we propose a new Computer-Aided Detection (CAD) system using CNNs and CT image segmentation techniques. Unlike former studies focusing on the classification of malignant nodule types or relying on prior image processing, in this work, we put raw CT image patches directly in CNNs to reduce the complexity of the system. Specifically, we split each CT image into several patches, which are divided into 6 types consisting of 3 nodule types and 3 non-nodule types. We compare the performance of ResNet with different CNNs architectures on CT images from a publicly available dataset named the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI). Results show that our best model reaches a high detection sensitivity of 92.8% with 8 false positives per scan (FPs/scan). Compared with related work, our work obtains a state-of-the-art effect.
Similar content being viewed by others
References
Siegel RL, Miller KD, Jemal A: Cancer statistics, 2015. CA Cancer J Clin 65(1):5–29, 2015
Ma L, Wang DD, Zou B, Yan H: An eigen-binding site based method for the analysis of anti-EGFR drug resistance in lung cancer treatment. IEEE/ACM Trans Comput Biol Bioinform 14(5):1187–1194, 2017
Kaneko M, Eguchi K, Ohmatsu H, Kakinuma R, Naruke T, Suemasu K, Moriyama N: Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. Radiology 201(3):798–802, 1996
Jiang H, Ma H, Qian W et al.: An automatic detection system of lung nodule based on multi-group patch-based deep learning network. IEEE J Biomed Health Inform 22:1227–1237, 2017
Messay T, Hardie RC, Rogers SK: A new computationally efficient CAD system for pulmonary nodule detection in CT imagery. Med Image Anal 14(3):390–406, 2010
Gurcan MN, Sahiner B, Petrick N, Chan HP, Kazerooni EA, Cascade PN, Hadjiiski L: Lung nodule detection on thoracic computed tomography images: Preliminary evaluation of a computer-aided diagnosis system. Med Phys 29(11):2552–2558, 2002
Aerts HJ, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Carvalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun 5:4006, 2014
Balagurunathan Y, Gu Y, Wang H, Kumar V, Grove O, Hawkins S, Kim J, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ: Reproducibility and prognosis of quantitative features extracted from CT images. Transl Oncol 7(1):72–87, 2014
Rendon-Gonzalez E, Ponomaryov V: Automatic lung nodule segmentation and classification in CT images based on SVM. International Kharkiv Symposium on Physics and Engineering of Microwaves, Millimeter and Submillimeter Waves. IEEE 1–4, 2016
Lee S L A, Kouzani A Z, Hu E J: A random forest for lung nodule identification. TENCON 2008 - 2008 IEEE Region 10 Conference. IEEE:1–5, 2008
Adetiba E, Olugbara OO: Lung cancer prediction using neural network ensemble with histogram of oriented gradient genomic features. ScientificWorldJourna 2015:1–17, 2015. https://doi.org/10.1155/2015/786013
Shan C: Learning local binary patterns for gender classification on real-world face images. Pattern Recognit Lett 33(4):431–437, 2012
Orozco HM, Villegas OOV, Sánchez VGC, Domínguez HJO, Alfaro MJN: Automated system for lung nodules classification based on wavelet feature descriptor and support vector machine. Biomed Eng Online 14(1):9, 2015
Tartar A, Akan A, Kilic N: A novel approach to malignant-benign classification of pulmonary nodules by using ensemble learning classifiers. Conf Proc IEEE Eng Med Biol Soc: 4651–4654, 2014
Kang G, Liu K, Hou B, Zhang N: 3D multi-view convolutional neural networks for lung nodule classification. PLoS One 12:e0188290, 2017. https://doi.org/10.1371/journal.pone.0188290
Han F, Wang H, Zhang G, Han H, Song B, Li L, Moore W, Lu H, Zhao H, Liang Z: Texture feature analysis for computer-aided diagnosis on pulmonary nodules. J Digit Imaging 28(1):99–115, 2015
Hinton GE, Osindero S, Teh YW: A fast learning algorithm for deep belief nets. Neural Comput, 2006. https://doi.org/10.1162/neco.2006.18.7.1527
Szegedy C, Liu W, Jia Y, Sermanet P, Reed S, Anguelov D, Erhan D, Vanhoucke V, Rabinovich A: Going deeper with convolutions. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit, 2015.
Ren S, He K, Girshick R, Sun J: Faster r-cnn: towards real-time object detection with region proposal networks. Adv Neural Inf Process Syst: 91–99, 2015
Liang-Chieh C, Papandreou G, Kokkinos I, Murphy K, Yuille A: Semantic image segmentation with deep convolutional nets and fully connected crfs. International Conference on Learning Representations, 2015
Krizhevsky A, Sutskever I, Hinton GE: Imagenet classification with deep convolutional neural networks. Adv Neural Inf Process Syst:1097–1105, 2012
Simonyan K, Zisserman A: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556, 2014
He K, Zhang X, Ren S, Sun J: Deep residual learning for image recognition. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit 770–778, 2016
Golan R, Jacob C, Denzinger J: Lung nodule detection in CT images using deep convolutional neural networks. International Joint Conference on Neural Networks: 243–250. 2016
Wang S, Zhou M, Gevaert O, Tang Z, Dong D, Liu Z, Tian J: A multi-view deep convolutional neural networks for lung nodule segmentation. Conf Proc IEEE Eng Med Biol Soc 2017, 1752–1755
Liu K, Kang G: Multiview convolutional neural networks for lung nodule classification. Int J Imaging Syst Technol, DOI:https://doi.org/10.1002/ima.22206, 2017
Huang X, Shan J, Vaidya V: Lung nodule detection in CT using 3D convolutional neural networks. 2017 IEEE 14th International Symposium on Biomedical Imaging 379–383, 2017
Gu Y, Lu X, Yang L, Zhang B, Yu D, Zhao Y, Gao L, Wu L, Zhou T: Automatic lung nodule detection using a 3D deep convolutional neural network combined with a multi-scale prediction strategy in chest CTs. Comput. Biol. Med. 103:220–231, 2018
Zhu W, Liu C, Fan W, Xie X: Deeplung: Deep 3d dual path nets for automated pulmonary nodule detection and classification. 2018 IEEE Winter Conf. Appl. Comput. Vision, WACV: 673-681, 2018
Armato SG, McLennan G, Bidaut L, McNitt-Gray MF, Meyer CR, Reeves AP, Zhao B, Aberle DR, Henschke CI, Hoffman EA, Kazerooni EA: The lung image database consortium (LIDC) and image database resource initiative (IDRI): a completed reference database of lung nodules on CT scans. Med Phys 38(2):915–931, 2011
Van Ginneken B, Setio AA, Jacobs C, Ciompi F: Off-the-shelf convolutional neural network features for pulmonary nodule detection in computed tomography scans. IEEE Int. Symp. Biomed. Imaging:286–289, 2015
Han F, Zhang G, Wang H, et al: A texture feature analysis for diagnosis of pulmonary nodules using LIDC-IDRI database. IEEE International Conference on Medical Imaging Physics and Engineering, 2014, 14–18.
Htwe K Z, Yamamori K, Katayama T, Kyi T M: Automated lung nodule classification by artificial neural network and fuzzy inference system. Consumer Electronics, 2016 IEEE, Global Conference on IEEE, 2016 1–2.
Van Ginneken B, Armato SG, de Hoop B, van Amelsvoort-van de Vorst S, Duindam T, Niemeijer M, Murphy K, Schilham A, Retico A, Fantacci ME, Camarlinghi N: Comparing and combining algorithms for computer-aided detection of pulmonary nodules in computed tomography scans: the ANODE09 study. Med Image Anal 14(6):707–722, 2011
Fawcett T: An introduction to ROC analysis. Pattern Recognit Lett 27(8):861–874, 2006
Setio AAA, Ciompi F, Litjens G, Gerke P, Jacobs C, van Riel SJ, Wille MMW, Naqibullah M, Sanchez CI, van Ginneken B: Pulmonary nodule detection in CT images: false positive reduction using multi-view convolutional networks. IEEE Trans Med Imaging 35(5):1160–1169, 2016
Jiang H, Ma H, Qian W, Gao M, Li Y: An automatic detection system of lung nodule based on multi-group patch-based deep learning network. IEEE J Biomed Health Inform (99):1–1, 2017
Khosravan N, Bagci U: S4ND: Single-shot single-scale lung nodule detection. Med Image Comput Comput Assist Interv:794–802, 2018
Broyelle A: Automated Pulmonary Nodule Detection on Computed Tomography Images with 3D Deep Convolutional Neural Network, School of Computer Science and Communication KTHRoyal Institute of Technology, Stockholm 2018.
Dou Q, Chen H, Jin Y, Lin H, Qin J, Heng PA: Automated pulmonary nodule detection via 3d convnets with online sample filtering and hybrid-loss residual learning. Med Image Comput Comput Assist Interv:630–638, 2017
Acknowledgments
This work is supported in part by National Natural Science Foundation of China (61772331). We would also like to thank the Shanghai Chest Hospital and department of micro/nanoelectronics at Shanghai Jiao Tong University.
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic Supplementary Material
ESM 1
(HDF5 50,485 kb)
Rights and permissions
About this article
Cite this article
Wang, Q., Shen, F., Shen, L. et al. Lung Nodule Detection in CT Images Using a Raw Patch-Based Convolutional Neural Network. J Digit Imaging 32, 971–979 (2019). https://doi.org/10.1007/s10278-019-00221-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10278-019-00221-3