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Effects of Reversible Inhibition of Cholinesterase and Nicotine on Mouse Mortality and Blood Levels of Proinflammatory Cytokines during the Early Phase of Sepsis

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Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL50 injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-α, IL-1β, and IL-6.

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Authors and Affiliations

  1. V. I. Razumovskii State Medical University, Saratov, Russia

    P. F. Zabrodskii, V. G. Lim & A. V. Kuzmin

Authors
  1. P. F. Zabrodskii
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  2. V. G. Lim
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  3. A. V. Kuzmin
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Correspondence to P. F. Zabrodskii.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 11, pp. 531-533, November, 2011

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Zabrodskii, P.F., Lim, V.G. & Kuzmin, A.V. Effects of Reversible Inhibition of Cholinesterase and Nicotine on Mouse Mortality and Blood Levels of Proinflammatory Cytokines during the Early Phase of Sepsis. Bull Exp Biol Med 152, 600–602 (2012). https://doi.org/10.1007/s10517-012-1585-z

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  • DOI: https://doi.org/10.1007/s10517-012-1585-z

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