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Role of Nicotinic and Muscarinic Cholinoreceptors in the Realization of the Cholinergic Anti-Infl ammatory Pathway during the Early Phase of Sepsis

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Bulletin of Experimental Biology and Medicine Aims and scope

Stimulation of nicotinic and muscarinic cholinoreceptors (nAChR, mAChR) in outbred albino mice with nicotine and aceclidine, respectively, in single equilethal doses 0.5 DL50 6 h before sepsis induction signifi cantly reduced animal mortality due to a decrease in blood concentrations of proinfl ammatory cytokines IL-1β, IL-6, and MIP-2. Stimulation of mAChR (injection of aceclidine) stimulated the neutrophilic phagocytic and metabolic activity. Realization of the cholinergic anti-infl ammatory pathway (stimulation of the peripheral nicotinic cholinoreceptors (α7nAChR) and central muscarinic cholinoreceptors (mAChR) was modulated by stimulation of the muscarinic cholinoreceptors of the phagocytic monocytic system cells.

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Authors and Affiliations

  1. V. I. Razumovskii State Medical University, Saratov, Russia

    P. F. Zabrodskii, V. G. Lim, M. S. Shekhter & A. V. Kuzmin

Authors
  1. P. F. Zabrodskii
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  2. V. G. Lim
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  3. M. S. Shekhter
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  4. A. V. Kuzmin
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Corresponding author

Correspondence to P. F. Zabrodskii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 656-659, May, 2012

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Zabrodskii, P.F., Lim, V.G., Shekhter, M.S. et al. Role of Nicotinic and Muscarinic Cholinoreceptors in the Realization of the Cholinergic Anti-Infl ammatory Pathway during the Early Phase of Sepsis. Bull Exp Biol Med 153, 700–703 (2012). https://doi.org/10.1007/s10517-012-1803-8

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  • DOI: https://doi.org/10.1007/s10517-012-1803-8

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