Emopag, a new drug, preventively administered in doses of 10 and 30 mg/kg/day over 4 days produced a pronounced neuroprotective effect in the model of brain ischemia caused by gravitational overload and reduced animal mortality from 17 to 0%. The preparation more effectively corrected neurological deficit than the reference drugs Mexidol (in considerably larger doses of 30 and 90 mg/kg/day) and antihypoxic drug amtizol (30 mg/kg/day). Moreover, Emopag exhibited considerable antiamnestic activity comparable to that of Mexidol (in 3-fold higher doses); in a dose of 30 mg/kg/day Emopag was more effective than Mexidol and amtizol in the same dose. Thus, Emopag showed marked neuroprotective and antiamnestic effects in the model of gravitational overload in rats.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 8, pp. 201-204, August, 2019
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Yasnetsov, V.V., Voronina, T.A., Skachilova, S.Y. et al. Neuroprotective and Antiamnestic Effects of a New Drug Emopag in Rats. Bull Exp Biol Med 168, 247–249 (2019). https://doi.org/10.1007/s10517-019-04684-w
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DOI: https://doi.org/10.1007/s10517-019-04684-w