For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or high-fat diet. In 3 weeks, diabetes mellitus was modeled by single intraperitoneal injection of streptozotocin. Changes in hematological parameters, physical and biochemical parameters of the urine, and in the development of thermal allodynia were different after 15-week standard and high-fat diets.
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Aydın AF, Bingül İ, Küçükgergin C, Doğan-Ekici I, Doğru Abbasoğlu S, Uysal M. Carnosine decreased oxidation and glycation products in serum and liver of high-fat diet and lowdose streptozotocin-induced diabetic rats. Int. J. Exp. Pathol. 2017;98(5):278-288.
Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, Hughes TM, Craft S, Freedman BI, Bowden DW, Vinik AI, Casellini CM. Diabetic microvascular disease: an Endocrine Society scientific statement. J. Clin. Endocrinol. Metab. 2017;102(12):4343-4410.
Byrne FM, Cheetham S, Vickers S, Chapman V. Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J. Diabetes Res. 2015;2015:752481. doi: https://doi.org/10.1155/2015/752481
Magalhães DA, Kume WT, Correia FS, Queiroz TS, Allebrandt Neto EW, Santos MPD, Kawashita NH, França SA. High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal. An. Acad. Bras. Cienc. 2019;91(1):e20180314. doi: https://doi.org/10.1590/0001-3765201920180314
Runtuwene J, Cheng KC, Asakawa A, Amitani H, Amitani M, Morinaga A, Takimoto Y, Kairupan BH, Inui A. Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4. Drug Des. Dev. Ther. 2016;10:2193-2202.
Salvador ÂC, Król E, Lemos VC, Santos SA, Bento FP, Costa CP, Almeida A, Szczepankiewicz D, Kulczyński B, Krejpcio Z, Silvestre AJ, Rocha SM. Effect of elderberry (Sambucus nigra L.) extract supplementation in STZ-induced diabetic rats fed with a high-fat diet. Int. J. Mol. Sci. 2016;18(1). pii: E13. doi: https://doi.org/10.3390/ijms18010013
Strugała P, Dzydzan O, Brodyak I, Kucharska A.Z, Kuropka P, Liuta M, Kaleta-Kuratewicz K, Przewodowska A, Michałowska D, Gabrielska J, Sybirna N. Antidiabetic and antioxidative potential of the blue congo variety of purple potato extract in streptozotocin-induced diabetic rats. Molecules. 2019;24(17). pii: E3126. doi: https://doi.org/10.3390/molecules24173126
Zhang M, Lv XY, Li J, Xu ZG, Chen L. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp. Diabetes Res. 2008;2008:704045.doi: https://doi.org/10.1155/2008/704045
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 12, pp. 720-724, December, 2020
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Shaykhutdinova, E.R., Palikov, V.A., Palikova, Y.A. et al. Effect of Standard and High-Fat Diets during Modeling of Streptozotocin-Induced Diabetes in Rats on the Development of Complications. Bull Exp Biol Med 170, 737–740 (2021). https://doi.org/10.1007/s10517-021-05144-0
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DOI: https://doi.org/10.1007/s10517-021-05144-0