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Microparticle based morphology engineering of filamentous microorganisms for industrial bio-production

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Abstract

Filamentous microorganisms are important work horses in industrial biotechnology and supply enzymes, antibiotics, pharmaceuticals, bulk and fine chemicals. Here we highlight recent findings on the use of microparticles in the cultivation of filamentous bacteria and fungi, with the aim of enabling a more precise control of their morphology towards better production performance. First examples reveal a broad application range of microparticle based processes, since multiple filamentous organisms are controllable in their growth characteristics and respond by enhanced product formation.

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Acknowledgments

All authors acknowledge financial support by the Allianz Industrie Forschung in the project “Microparticle based cultivation of filamentous fungi” (IGF: 16926 N/2). Christoph Wittmann and Rainer Krull additionally acknowledge support by the Collaborative Research Center SFB 578 “From gene to product” at Technische Universität Braunschweig, Germany, funded by the German Research Foundation.

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Authors and Affiliations

  1. Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaußstraße 17, 38106, Braunschweig, Germany

    Robert Walisko, Rainer Krull & Christoph Wittmann

  2. Biochemical Engineering Group, DECHEMA Research Institute, Frankfurt, Germany

    Jens Schrader

Authors
  1. Robert Walisko
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  2. Rainer Krull
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  3. Jens Schrader
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  4. Christoph Wittmann
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Correspondence to Christoph Wittmann.

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Walisko, R., Krull, R., Schrader, J. et al. Microparticle based morphology engineering of filamentous microorganisms for industrial bio-production. Biotechnol Lett 34, 1975–1982 (2012). https://doi.org/10.1007/s10529-012-0997-1

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  • DOI: https://doi.org/10.1007/s10529-012-0997-1

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