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Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms

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Abstract

Purpose

Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase.

Methods

The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis.

Results

The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11–1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25–2.70) and multiple adenomas (OR 1.72, 95% CI 1.26–2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13–1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58–1.24).

Conclusion

Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.

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Acknowledgments

This study was supported in part by Grants NCC-1410250-3, NCC-1610250, and NCC-0910221 from National Cancer Center, Korea. The authors thank Jeong-Hee Lee, MS for their help in manuscript preparation.

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Authors and Affiliations

  1. Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea

    Ji Hyung Nam, Chang Won Hong, Byung Chang Kim, Kum Hei Ryu, Bum Joon Park, Bun Kim, Dae Kyung Sohn, Kyung Su Han & Chan Wha Lee

  2. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea

    Chang Won Hong, Byung Chang Kim, Bun Kim, Dae Kyung Sohn & Kyung Su Han

  3. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Aesun Shin

  4. Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Republic of Korea

    Aesun Shin & Jeongseon Kim

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  1. Ji Hyung Nam
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Correspondence to Chang Won Hong.

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Nam, J.H., Hong, C.W., Kim, B.C. et al. Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms. Cancer Causes Control 28, 107–115 (2017). https://doi.org/10.1007/s10552-016-0839-x

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  • DOI: https://doi.org/10.1007/s10552-016-0839-x

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