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New aspects on the assessment of left ventricular dyssynchrony by tissue Doppler echocardiography: comparison of myocardial velocity vs. displacement curves

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Abstract

The purpose of this study is to assess the incremental value of tissue Doppler (TDI) derived displacement curves (TDint) compared to TDI velocity curves (TDvel) for the evaluation of left ventricular (LV) dyssynchrony (LVD). About 25 patients (pts.) with systolic heart failure were studied by TDvel and TDint. Four TDI sample volumes were placed at the basal and four at the mid ventricular myocardium, utilising two imaging planes. LV dyssynchrony (LVD) was defined as an interregional delay of >40 ms corrected for heart rate. 10 pts. had synchronous contraction, 15 pts. LVD as defined by two experts (EC). To determine diagnostic accuracy and intra-observer variability two identical sets of 100 documents (25 pts. × two imaging planes × two modalities) were produced and presented in random order to one trained (TR) and two untrained (UR) readers. The TR more frequently classified documents as unreadable (7.5 vs. 3.5%, P < 0.05) but more often as correct, i.e., consistent with EC (72.0 vs. 57.8%, P < 0.001). 8.7% of the documents were classified as unreadable using TDvel, 1.0% when applying TDint (P < 0.001). The mean value of correct classification of all 3 readers was 54.3% (TDvel only), 70.7% (TDint only), and 77.7% (combining both modalities), (P < 0.001). The kappa value for TR and TDint was 0.68, for TDvel 0.29. For UR, kappa did not differ (TDint: 0.58; TDvel 0.51). TDint is superior to TDvel in accuracy, reproducibility, and applicability for skilled and unskilled investigators when evaluating LVD by TDI. The combined application of TDint and TDvel is optimal.

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References

  1. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Messenger J for the MIRACLE study group (2002) Cardiac resynchronisation in chronic heart failure. New Engl J Med 346:1845–1853

    Google Scholar 

  2. Aranda JM, Carlson ER, Pauly DF, Curtis AB, Conti RC, Ariet M, Hill JA (2002) QRS duration variability in patients with heart failure. Am J Cardiol 9:335–337

    Article  Google Scholar 

  3. Auricchio A, Salo R (1997) Acute hemodynamic improvement by pacing in patients with severe congestive heart failure. Pacing Clin Electrophysiol 20:313–324

    Article  PubMed  CAS  Google Scholar 

  4. Breithardt OA, Stellbrink C, Kramer AP, Sinha AM, Franke A, Salo R, Schiffgens B, Huvelle E, Auricchio A, PATH-CHF study group (2002) Echocardiographic quantification of left ventricular asynchrony predicts an acute hemodynamic benefit of cardiac resynchronization therapy. J Am Coll Cardiol 40:536–545

    Article  PubMed  Google Scholar 

  5. Derumeaux G, Ovize M, Loufoua J, Pontier G, Andre-Fouet X, Cribier A (2000) Assessment of nonuniformity of transmural myocardial velocities by color-coded tissue doppler imaging. Circulation 101:1390–1395

    PubMed  CAS  Google Scholar 

  6. Faber L, Lamp B, Vogt J, Heintze J, Hansky B, Körfer R, Horstkotte D (2004) Tissue Doppler imaging in patients with congestive heart failure and conduction disorders. Eur Heart J 6(Suppl D):D10–D16

    Google Scholar 

  7. Schuster P, Faerestrand S, Ohm OJ (2003) Colour tissue velocity imaging can show resynchronisation of longitudinal LV contraction patterns by biventricular pacing in patients with severe heart failure. Heart 89:859–864

    Article  PubMed  CAS  Google Scholar 

  8. Wilkensdorff UM, Sovany A, Wigström L, Olstad B, Lindström L, Engvall J, Janerot-Sjöberg B, Bengt W, Hatle L, Sutherland GR (1998) Regional mean systolic myocardial velocity estimation by real-time color doppler myocardial imaging: a new technique for quantifying regional systolic function. JASE 11:683–692

    Google Scholar 

  9. Chung ES, Leon AR, Tavazzi L et al (2008) Results of the predictors of response to CRT (PROSPECT) trial. Circulation 117:2608–2616

    Article  PubMed  Google Scholar 

  10. Beshai JF, Grimm RA, Nagueh SF, Baker JH, Beau SL, Greenberg SM, Pires LA, Tchou PJ (2007) Cardiac resynchronization therapy in heart failure with narrow QRS complexes. N Engl J Med 357:2461

    Article  PubMed  CAS  Google Scholar 

  11. Ahnve S (1985) Correction of the QT interval for heart rate: review of different formulas and the use of Bazett`s formula in myocardial infarction. Am Heart J 109:568–574

    Article  PubMed  CAS  Google Scholar 

  12. Bazett HC (1920) An analysis of the time-relations of electrocardiograms. Heart 7:353–370

    Google Scholar 

  13. Feinstein AR, Cicchetti DV (1990) High agreement but low kappa: I.The problems of two paradoxes. J Clin Epidemiol 43:543–549

    Article  PubMed  CAS  Google Scholar 

  14. Maclure M, Willett WC (1987) Misinterpretation and misuse of the kappa statistic. Am J Epidemiol 126:161–169

    PubMed  CAS  Google Scholar 

  15. McGinn T, Weyer PC, Newman TB, Keitz S, Leipzig R, Guyatt G (2004) Tips for teachers of evidence-based medicine: 3. Understanding and calculating kappa. Can Med Assoc J 171:1369–1373

    Article  Google Scholar 

  16. Makaryus AN, Arduini AD, Mallin J, Chung E, Kort S, Shi Q, Jadonath R, Mangion J (2003) Echocardiographic features of patients with heart failure who may benefit from biventricular pacing. Echocardiography 20:217–223

    Article  PubMed  Google Scholar 

  17. Bax JJ, Molhoek SG, Marwick TH, van Erven L, Voogd PJ, Somer S, Boersma E, Steendijk P, Schalij MJ, Van der Wall EE (2003) Usefulness of myocardial tissue Doppler echocardiography to evaluate left ventricular dyssynchrony before and after biventricular pacing in patients with idiopathic dilated cardiomyopathy. Am J Cardiol 91:94–97

    Article  PubMed  Google Scholar 

  18. Garrigue S, Reuter S, Labeque JN, Jais P, Hocini M, Shah DC, Haissaguerre M, Clementy J (2001) Usefulness of biventricular pacing in patients with congestive heart failure and right bundle branch block. Am J Cardiol 88:1436–1441

    Article  PubMed  CAS  Google Scholar 

  19. Penicka M, Bartunek J, De Bruyne B, Vanderheyden M, Goethals M, De Zutter M, Brugada P, Geelen P (2004) Improvement of left ventricular function after cardiac resynchronisation therapy is predicted by tissue Doppler imaging echocardiography. Circulation 109:978–983

    Article  PubMed  Google Scholar 

  20. Søgaard P, Egeblad H, Kim WY, Jensen HK, Pederson AK, Kristensen BØ, Mortensen PT (2002) Tissue doppler imaging predicts improved systolic performance and reversed left ventricular remodeling during long-term cardiac resynchronization therapy. J Am Coll Cardiol 40:723–730

    Article  PubMed  Google Scholar 

  21. Søgaard P, Hassager C (2004) Tissue Doppler imaging as a guide to resynchronization therapy in patients with congestive heart failure. Curr Opin Cardiol 19:447–451

    Article  PubMed  Google Scholar 

  22. Yu CM, Fung WH, Zhang Q, Chan CK, Chan YS, Lin H, Kum LC, Kong SL, Zhang Y, Sanderson JE (2004) Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and non-ischemic heart failure after cardiac resynchronization therapy. Circulation 110:66–73

    Article  PubMed  Google Scholar 

  23. Yu CM, Chau E, Sanderson JE, Fan K, Tang MO, Fung WH, Lin H, Kong SL, Lam YM, Hill MRS, Lau CP (2002) Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 105:438–445

    Article  PubMed  Google Scholar 

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Correspondence to N. Bogunovic.

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Bogunovic, N., Hering, D., van Buuren, F. et al. New aspects on the assessment of left ventricular dyssynchrony by tissue Doppler echocardiography: comparison of myocardial velocity vs. displacement curves. Int J Cardiovasc Imaging 25, 699–704 (2009). https://doi.org/10.1007/s10554-009-9484-8

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  • DOI: https://doi.org/10.1007/s10554-009-9484-8

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