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Assessment of biventricular systolic strain derived from the two-dimensional and three-dimensional speckle tracking echocardiography in lymphoma patients after anthracycline therapy

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Abstract

The aim of this study was to investigate the usefulness of three-dimensional (3D) speckle tracking echocardiography (STE) for assessment of both left and right ventricular systolic function in patients with lymphoma after anthracycline chemotherapy, compared with two-dimensional (2D) STE. Totally eighty-nine patients undergoing anthracycline containing chemotherapy were studied. Echocardiographic assessment included 2D and 3D left ventricular (LV) global longitudinal strain (GLS), global circumferential strain (GCS) and right ventricular (RV) GLS. All the parameters were analyzed at baseline, after the completion of four cycles and at the end of the regimen respectively. The area under the receiver operating characteristic curve was calculated to determine the capability of various echocardiographic parameters to discriminate between before and after chemotherapy. Compared with those at baseline, the 3D GLS and GCS of LV and GLS of RV decreased significantly after four cycles of the therapy (all p < 0.01). At the end of the treatment, 2D GLS and GCS of LV deteriorated markedly (both p < 0.05). The area under the curve for GLS, GCS of LV and GLS of RV derived by 3D were 0.81, 0.66 and 0.78, respectively. The cutoff value with −20.4% of LV GLS by 3D had sensitivity of 81% and specificity of 66% for differentiating patients after therapy from baselines. The cutoff value with −21.9% of RV GLS by 3D had sensitivity of 71% and specificity of 74% fordifferentiating patients after therapy from baselines. The data from this study demonstrated that both 2D and 3D STE can be conducted to evaluate the slight myocardial damage for lymphoma patients after anthracycline chemotherapy. 3D STE could examine subclinical biventricular dysfunction in earlier point than 2D STE.

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Funding

This work was supported by programs from the National Nature Science Foundation of China (81201095) and the Excellence Award for Youth Talent of Zhongshan Hospital, Fudan University (2015ZSYXGG04).

Authors’ contributions

LC and YG designed the study, FS and JS carried the study, FS, CZ, YX and QZ analyzed the study’s data, FS, JS and XS wrote the manuscript, LC and YG corrected the manuscript. All authors approved the final version of the manuscript.

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    Authors and Affiliations

    1. Department of Echocardiography, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

      Fei-Yan Song, Jing Shi, Chu-Jie Zhang, Yu-Chen Xu, Xian-Hong Shu & Lei-Lei Cheng

    2. Department of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, China

      Ye Guo & Qun-Ling Zhang

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    1. Fei-Yan Song
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    All subjects provided informed consent for participation in the study and for the administration of anthracycline therapy. The local ethics committee approved the protocol (the ethics approval number of Fudan University Shanghai Cancer Center is: 1212117-6, the ethics approval number of Zhongshan Hospital of Fudan University is: 2011-117).

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    Fei-Yan Song and Jing Shi have contributed equally.

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    Song, FY., Shi, J., Guo, Y. et al. Assessment of biventricular systolic strain derived from the two-dimensional and three-dimensional speckle tracking echocardiography in lymphoma patients after anthracycline therapy. Int J Cardiovasc Imaging 33, 857–868 (2017). https://doi.org/10.1007/s10554-017-1082-6

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