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Preparation and characterization of cellulose microspheres

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Abstract

The aim of this work was to synthesize and characterize cellulose microspheres with a particle size below 5 μm and narrow size distribution. After activation and functionalization with antibodies, these particles shall be applied as adsorbents in suspension-based extracorporeal blood purification systems, such as the Microspheres-Based Detoxification System. In the frame of this work such microspheres were developed and synthesized with reproducible properties. Besides using well-established methods for characterization of this kind of bead cellulose, additional procedures for the examination of its properties were developed and applied.

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References

  • Ash SR, Sullivan TA, Carr DJ (2006) Sorbent suspensions versus sorbent columns for extracorporeal detoxification in hepatic failure. Ther Apher Dial 10:145–153

    Article  CAS  Google Scholar 

  • Bohren CF, Huffman DR (1998) Absorption and scattering of light by small particles. Wiley, New York

    Book  Google Scholar 

  • de Oliveira W, Glasser WG (1996a) Hydrogels from polysaccharides. I. Cellulose beads for chromatographic support. J Appl Polym Sci 60:63–73

    Article  Google Scholar 

  • de Oliveira W, Glasser WG (1996b) Hydrogels from polysaccharides. II. Beads with cellulose derivatives. J Appl Polym Sci 61:81–86

    Article  Google Scholar 

  • Falkenhagen D, Brandl M, Hartmann J, Kellner KH, Posnicek T, Weber V (2006) Fluidized bed adsorbent systems for extracorporeal liver support. Ther Apher Dial 10:154–159

    Article  Google Scholar 

  • Feldner A (2009) Entwicklung von Methoden zur Charakterisierung von Perlcellulosen. Master’s thesis, TU Dresden (Institute of plant and wood chemistry)

  • Fischer S, Thümmler K, Volkert B, Hettrich K, Schmidt I, Fischer K (2008) Properties and applications of cellulose acetate. Macromol Symp 262:89–96

    Article  CAS  Google Scholar 

  • Fraunhofer J (1817) Bestimmung des Brechungs- und Farbzerstreuungsvermögens verschiedener Glasarten. Gilberts Ann Phys 56:193–226

    Google Scholar 

  • Heinze Th, Liebert T (2004) Chemical characteristics of cellulose acetate. Macromol Symp 208:167–237

    Article  CAS  Google Scholar 

  • Jones RM (2003) Particle size analysis by laser diffraction: ISO 13320, standard operating procedures and Mie theory. Am Lab 35:44–47

    CAS  Google Scholar 

  • Kaster JA, de Oliveira W, Glasser WG, Velander WH (1993) Optimization of pressure-flow limits, strength, intraparticle transport and dynamic capacity by hydrogel solids content and bead size in cellulose immunosorbents. J Chromatogr A 648:79–90

    Article  CAS  Google Scholar 

  • Kuga S (1980) New cellulose gel for chromatography. J Chromatogr 195:221–230

    Article  CAS  Google Scholar 

  • Mie G (1908) Beiträge zur Optik trüber Medien, speziell kolloidaler Metalllösungen. Ann Phys 330:377–445

    Article  Google Scholar 

  • Naining W, Hongjian Z (1986) A study of the accuracy of optical Fraunhofer diffraction size analyser. Part Sci Technol 4:403–408

    Article  CAS  Google Scholar 

  • O`Neill JJ, Reichardt EP (1951) Cellulose pellets. US 2543928

  • Peška J, Štamberg J, Hradil J, Ilavský M (1976) Cellulose in bead form: properties related to chromatographic uses. J Chromatogr 125:455–469

    Article  Google Scholar 

  • Sobisch T, Lerche D, Fischer S, Fanter C (2006) Characterization of porous bead celluloses by analytical centrifugation. Prog Colloid Polym Sci 133:169–172

    Article  CAS  Google Scholar 

  • Volkert B, Wolf B, Fischer S, Li N, Lou C (2009) Applications of modified bead cellulose as a carrier of active ingredients. Macromol Symp 280:130–135

    Article  CAS  Google Scholar 

  • Wagenknecht W, Fanter C, Loth F (1996) Process for producing spherical microparticles on the basis of cellulose acetate. EP 0750007

  • Weber V, Hartmann J, Linsberger I, Falkenhagen D (2007) Efficient adsorption of tumor necrosis factor with an in vitro set-up of the Microspheres-Based Detoxification System. Blood Purif 25:169–174

    Article  CAS  Google Scholar 

  • Weber V, Ettenauer M, Linsberger I, Loth F, Thümmler K, Feldner A, Fischer S, Falkenhagen D (2010) Functionalization and application of cellulose microparticles as adsorbents for extracorporeal blood purification. Macromol Symp 294:90–95

    Article  CAS  Google Scholar 

  • Wolf B, Horsch W (1991) Herstellung, Eigenschaften und Verwendung der Perlcellulose—eine Übersicht. Pharmazie 46:392–402

    CAS  Google Scholar 

  • Wolf B, Schmitz W, Schneider H (1996) Composites of bead cellulose and hydrophilic solubiliziers. Int J Pharm 139:87–94

    Article  CAS  Google Scholar 

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Acknowledgments

The authors are indebted to Dr. Emanuele Martorana (Munich University of Applied Sciences), Dr. Jens Schaller (TITK Rudolstadt), Dr. Carola Fanter (IAP Potsdam) and Mr. Ernst Bäucker (Institute of Forest Utilization, TU Dresden) for their skillful support during performing the measurements.

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Authors and Affiliations

  1. Institute of plant and wood chemistry, Technische Universität Dresden, Pienner Str. 19, 01737, Tharandt, Germany

    Katrin Thümmler, Steffen Fischer & Alexander Feldner

  2. Center for Biomedical Technology, Danube University Krems, Dr.-Karl-Dorrek-Straße 30, 3500, Krems, Austria

    Viktoria Weber, Marion Ettenauer, Fritz Loth & Dieter Falkenhagen

Authors
  1. Katrin Thümmler
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  2. Steffen Fischer
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  3. Alexander Feldner
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  4. Viktoria Weber
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  5. Marion Ettenauer
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  6. Fritz Loth
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  7. Dieter Falkenhagen
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Correspondence to Katrin Thümmler.

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Thümmler, K., Fischer, S., Feldner, A. et al. Preparation and characterization of cellulose microspheres. Cellulose 18, 135–142 (2011). https://doi.org/10.1007/s10570-010-9465-z

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  • DOI: https://doi.org/10.1007/s10570-010-9465-z

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