Abstract
Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent. The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.
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Tortorella, S., Maturi, M., Dapporto, F. et al. Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics. Cellulose 27, 8503–8511 (2020). https://doi.org/10.1007/s10570-020-03390-5
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DOI: https://doi.org/10.1007/s10570-020-03390-5