Abstract
This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders.
Graphic Abstract
There are intimate connections between the brain and the digestive system. Gut microbiota dysbiosis activates the intestinal immune system, enhances intestinal permeability and bacterial translocation, leading to neuroinflammation, epigenetic changes, cerebrovascular alterations, amyloid β formation and α-synuclein protein aggregates. These alterations may participate in the development of hypertension, Alzheimer, Parkinson, stroke, epilepsy and autism. Brainstem nuclei such as the nucleus tractus solitarius (NTS) and the dorsal motor nucleus of the vagus (DMV) regulate gastric motor function by way of bidirectional inputs through the vagus nerve.
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The funding was supported by Georgetown University.
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YT and JMS equally contributed to the conception, design, drafting and revising the manuscript.
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Taché, Y., Saavedra, J.M. Introduction to the Special Issue “The Brain-Gut Axis”. Cell Mol Neurobiol 42, 311–313 (2022). https://doi.org/10.1007/s10571-021-01155-7
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DOI: https://doi.org/10.1007/s10571-021-01155-7