Abstract
A novel synthesis of the promising optically pure chiral (4R)-4-methylpentanolide that is based on several regiospecific oxidative transformations of (4R)-2,4-dimethyl-1-(1-methylethyl)-1-cyclohexene, the product of addition of (−)-menthone and methylmagnesium iodide followed by acid dehydration, was proposed.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 451–453, November–December, 2004.
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Ishmuratov, G.Y., Yakovleva, M.P., Zaripova, G.V. et al. Novel synthesis of (4R)-4-methylpentanolide from (L)-(−)-menthol. Chem Nat Compd 40, 548–551 (2004). https://doi.org/10.1007/s10600-005-0033-y
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DOI: https://doi.org/10.1007/s10600-005-0033-y