Bioassay-guided fractionation of the 70% methanolic extract of Lilium speciosum var. gloriosoides Baker resulted in the isolation of a new flavone C-glucoside, speciflavoside A (1), along with four known flavonoids (2–5). The structures of the isolates were assigned on the basis of spectroscopic data analysis, focusing on interpretation of 1D and 2D NMR, and MS data. All the isolates were tested for antiviral activity against respiratory syncytial virus (RSV). Compound 1 showed potent antiviral activity against RSV with IC50 value of 2.9 μg/mL and SI value of 30.9.
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Acknowledgment
This study was supported by the Scientific Research in the Education Department of Hunan Province (17C0150 and 17B034) and Hunan Key Laboratory Cultivation base of the research and development of novel pharmaceutical preparations (No. 2016TP1029).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2019, pp. 396–398.
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Chen, W., Zhang, H., Wang, J. et al. Flavonoid Glycosides From the Bulbs of Lilium speciosum var. gloriosoides and their Potential Antiviral Activity Against RSV. Chem Nat Compd 55, 461–464 (2019). https://doi.org/10.1007/s10600-019-02714-7
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DOI: https://doi.org/10.1007/s10600-019-02714-7