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Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities

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Abstract

Inflammation is the body’s response against various pathogens and has a critical role in numerous diseases. Zingerone (Zing), a bioactive substance derived from ginger root, has a variety of pharmacological properties, such as reducing inflammation, and antioxidant effects. We aimed to evaluate the beneficial effects of Zing in a carrageenan-induced inflammation model. Paw edema induced by carrageenan (100 μl of 1%) was used to induce acute inflammation in rats. Different doses of Zing (10, 20, and 40 mg/kg) were administered intraperitoneally. Paw tissue levels of MDA, NO, CAT, SOD, GPx, GSH, COX-2, PGE2, TNF-α, and IL-1β were estimated. Our results showed that Zing, especially at the highest dose of 40 mg/kg, significantly reduced paw swelling in carrageenan-injected animals. Zing significantly increased paw enzymatic and nonenzymatic antioxidants except CAT. It also decreased paw levels of MDA, NO, COX-2, PGE2, TNF-α, and IL-1β. The results of this study show that Zing may provide an alternative for the clinical control of inflammation through antioxidant and anti-inflammatory activities.

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Funding

This study was funded by the Deputy of Research, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (grant number: MPRC-9707).

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Authors and Affiliations

  1. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran

    Saeed Mehrzadi

  2. Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Hamidreza Khalili & Alireza Malayeri

  3. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

    Iman Fatemi

  4. Nab’a Al-Hayat Health Research Center, Nab’a Al-Hayat Foundation for Medical Sciences and Health Care, Najaf, Iraq

    Alireza Malayeri

  5. Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Amir Siahpoosh & Mehdi Goudarzi

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  1. Saeed Mehrzadi
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Correspondence to Mehdi Goudarzi.

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All procedures were conducted according to the Ethical Guideline for Research, Ahvaz University (Ethics code: IR.AJUMS.ABHC.REC.1397.002).

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Mehrzadi, S., Khalili, H., Fatemi, I. et al. Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities. Inflammation 44, 186–193 (2021). https://doi.org/10.1007/s10753-020-01320-y

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