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Destructive Roles of Fibroblast-like Synoviocytes in Chronic Inflammation and Joint Damage in Rheumatoid Arthritis

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A Correction to this article was published on 14 December 2020

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Abstract

Fibroblast-like synoviocytes (FLSs) are important non-immune cells located mostly in the inner layer of the synovium. Indeed, these cells are specialized mesenchymal cells, implicated in collagen homeostasis of the articular joint and provide extracellular matrix (ECM) materials for cartilage and contribute to joint destruction via multiple mechanisms. RA FLS interactions with immune and non-immune cells lead to the development and organization of tertiary structures such as ectopic lymphoid-like structures (ELSs), tertiary lymphoid organs (TLOs), and secretion of proinflammatory cytokines. The interaction of RA FLS cells with immune and non-immune cells leads to stimulation and activation of effector immune cells. Pathological role of RA FLS cells has been reported for many years, while molecular and cellular mechanisms are not completely understood yet. In this review, we tried to summarize the latest findings about the role of FLS cells in ELS formation, joint destruction, interactions with immune and non-immune cells, as well as potential therapeutic options in rheumatoid arthritis (RA) treatment. Our study revealed data about interactions between RA FLS and immune/non-immune cells as well as the role of RA FLS cells in joint damage, ELS formation, and neoangiogenesis, which provide useful information for developing new approaches for RA treatment.

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Funding

This research project was supported by Iran University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Clinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran

    Maryam Masoumi

  2. Department of Rheumatology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hamidreza Bashiri

  3. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Hossein Khorramdelazad, Khadijeh Barzaman, Hale Abdoli Sereshki & Jafar Karami

  4. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Hossein Khorramdelazad

  5. Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Hossein Khorramdelazad

  6. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Nader Hashemi

  7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  8. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  9. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

  10. Department of Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran

    Jafar Karami

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The original online version of this article was revised: The following statement must be added to the correspondence section: Jafar Karami at Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. E-mail: jafar_karami@yahoo.com; karami.jaf@iums.ac.ir

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Masoumi, M., Bashiri, H., Khorramdelazad, H. et al. Destructive Roles of Fibroblast-like Synoviocytes in Chronic Inflammation and Joint Damage in Rheumatoid Arthritis. Inflammation 44, 466–479 (2021). https://doi.org/10.1007/s10753-020-01371-1

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