Abstract
Seaweed is more than the wrap that keeps rice together in sushi. Seaweed biomass is already used for a wide range of other products in food, including stabilising agents. Biorefineries with seaweed as feedstock are attracting worldwide interest and include low-volume, high value-added products and vice versa. Scientific research on bioactive compounds in seaweed usually takes place on just a few species and compounds. This paper reviews worldwide research on bioactive compounds, mainly of nine genera or species of seaweed, which are also available in European temperate Atlantic waters, i.e. Laminaria sp., Fucus sp., Ascophyllum nodosum, Chondrus crispus, Porphyra sp., Ulva sp., Sargassum sp., Gracilaria sp. and Palmaria palmata. In addition, Undaria pinnatifida is included in this review as this is globally one of the most commonly produced, investigated and available species. Fewer examples of other species abundant worldwide have also been included. This review will supply fundamental information for biorefineries in Atlantic Europe using seaweed as feedstock. Preliminary selection of one or several candidate seaweed species will be possible based on the summary tables and previous research described in this review. This applies either to the choice of high value-added bioactive products to be exploited in an available species or to the choice of seaweed species when a bioactive compound is desired. Data are presented in tables with species, effect and test organism (if present) with examples of uses to enhance comparisons. In addition, scientific experiments performed on seaweed used as animal feed are presented, and EU, US and Japanese legislation on functional foods is reviewed.
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References
Aisa Y, Miyakawa Y, Nakazato T, Shibata H, Saito K, Ikeda Y, Kizaki M (2005) Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways. Am J Hematol 78:7–14
Alekseyenko TV, Zhanayeva SY, Venediktova AA, Zvyagintseva TN, Kuznetsova TA, Besednova NN, Korolenko TA (2007) Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga. Bull Exp Biol Med 143:730–732
Almela C, Algora S, Benito V, Clemente MJ, Devesa V, Suner MA, Velez D, Montoro R (2002) Heavy metal, total arsenic, and inorganic arsenic contents of algae food products. J Agric Food Chem 50:918–923
Amano H, Kakinuma M, Coury DA, Ohno H, Hara T (2005) Effect of a seaweed mixture on serum lipid level and platelet aggregation in rats. Fish Sci 71:1160–1166
Andersson L, Lidgren G, Bohlin L, Magni L, Ogren S, Afzelius L (1983) Studies of Swedish marine organisms. 1. Screening of biological-activity. Act Pharm Suec 20:401–414
Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. J Chromatogr B Analyt Technol Biomed Life Sci 803:41–53
Arasaki S, Arasaki T (1983) Low calorie, high nutrition vegetables from the sea to help you look and feel better. Japan Publications, Tokyo, 196 pp
Archer GS (2005) Reducing stress in sheep by feeding the seaweed Ascophyllum nodosum. Texas A&M University, 129 pp
Arnold TM, Targett NM (2000) Evidence for metabolic turnover of polyphenolics in tropical brown algae. J Chem Ecol 26:1393–1410
Arts ICW, Hollman PCH, De Mesquita HBB, Feskens EJM, Kromhout D (2001) Dietary catechins and epithelial cancer incidence: the Zutphen Elderly Study. Int J Cancer 92:298–302
Astorg P (1997) Food carotenoids and cancer prevention: an overview of current research. Trends Food Sci Technol 8:406–413
Athukorala Y, Lee KW, Kim SK, Jeon YJ (2007) Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea. Bioresour Technol 98:1711–1716
Augier H, Santimone M (1978) Contribution to study of composition in total nitrogen, proteins and proteinic amino-acids of different parts of thallus of Laminaria digitata (Huds) Lamour in scope of its industrial and agricultural exploitation. Bull Soc Phyc France 110:19–28
Baardseth E (1958) A method of estimating the physode content in brown algae-reprint of report 20. Papers Presented at the Third International Seaweed Symposium by the Staff of the Norwegian Institute of Seaweed Research, Norwegian Institute of Seaweed Research, Trondheim. Report 20, pp 1–6
Baardseth E, Haug A (1953) Individual variation of some constituents in brown algae, and reliability of analytical results. Norwegian Institute of Seaweed Research, Akademisk Trykningssentral, Oslo. Report 2, pp 1–23
Bansemir A, Blume M, Schröder S, Lindequist U (2006) Screening of cultivated seaweeds for antibacterial activity against fish pathogenic bacteria. Aquaculture 252:79–84
Barbarino E, Lourenço S (2005) An evaluation of methods for extraction and quantification of protein from marine macro- and microalgae. J Appl Phycol 17:447–460
Bartsch I, Wienke C, Bischof K, Buchholz CM, Buck BH, Eggert A, Feuerpfeil P, Hanelt D, Jacobsen S, Karez R et al (2008) The genus Laminaria sensu lato: recent insights and developments. Eur J Phycol 43:1–86
Benvegnu T, Sassi J-F (2010) Oligomannuronates from seaweeds as renewable sources for the development of green surfactants. Top Curr Chem 294:143–164
Berteau O, Mulloy B (2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13:29R–40R
Besada V, Andrade JM, Schultze F, Gonzalez JJ (2009) Heavy metals in edible seaweeds commercialised for human consumption. J Mar Syst 75:305–313
Bhakuni DS, Rawat DS (2005) Bioactive metabolites of marine algae, fungi and bacteria. In: Bioactive marine natural products. Co-published by Anamaya Publishers and Springer, New Delhi, pp 1–25
Bhaskar N, Hosokawa M, Miyashita K (2004) Comparative evaluation of fatty acid composition of different Sargassum (Fucales, Phaeophyta) species harvested from temperature and tropical waters. J Aquat Food Prod Technol 3:53–70
Bird KT, Chiles TC, Longley RE, Kendrick AF, Kinkema MD (1993) Agglutinins from marine macroalgae of the southeastern United States. J Appl Phycol 5:213–218
Bitencourt FD, Figueiredo JG, Mota MRL, Bezerra CCR, Silvestre PP, Nascimento VMR, KS SAH, Nagano CS, Saker-Sampaio S et al (2008) Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn-Schmiedebergs Arch Pharmacol 377:139–148
Bixler HJ, Porse H (2010) A decade of change in the seaweed hydrocolloids industry. J Appl Phycol. doi:10.1007/s10811-010-9529-3
Black WAP (1950) The seasonal variation in the cellulose content of the common Scottish Laminariaceae and Fucaceae. J Mar Biol Assoc UK 29:379–387
Blunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR (2003) Marine natural products. Nat Prod Rep 20:1–48
Bobin-Dubigeon C, Lahaye M, Barry JL (1997) Human colonic bacterial degradability of dietary fibres from sea-lettuce (Ulva sp.). J Sci Food Agric 73:149–159
Bogentoff CB (1981) Antacid composition for neutralizing stomach acid. Germany Patent No. 2,722,484
Borgo E (1984) Pharmaceutical compositions for the treatment of gastric hyperacidity, gastritis and gastroduodenal ulcers. Canada Patent No. 1,176,984
Boubonari T, Malea P, Kevrekidis T (2008) The green seaweed Ulva rigida as a bioindicator of metals (Zn, Cu, Pb and Cd) in a low-salinity coastal environment. Bot Mar 51:472–484
Brito I, Cueto M, Díaz-Marrero AR, Darias J, Martin AS (2002) Oxachamigrenes, new halogenated sesquiterpenes from Laurencia obtusa. J Nat Prod 65:946–948
Bruhn A, Rasmussen MB, Olesen B, Worm T (2008) Kommerciel dyrkning af carrageentang (Chondrus crispus) i danske farvande. Danmarks Miljøundersøgelser, Silkeborg, 62 pp (in Danish)
Buck CB, Thompson CD, Roberts JN, Muller M, Lowy DR, Schiller JT (2006) Carrageenan is a potent inhibitor of papillomavirus infection. PLoS Pathog 2:671–680
Burtin P (2003) Nutritional value of seaweeds. Electron J Environ Agric Food Chem 2:498–503
Butler A, Carter-Franklin JN (2004) The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products. Nat Prod Rep 21:180–188
Caceres PJ, Carlucci MJ, Damonte EB, Matsuhiro B, Zuniga EA (2000) Carrageenans from Chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity. Phytochemistry 53:81–86
Cann SAH (2006) Hypothesis: dietary iodine intake in the etiology of cardiovascular disease. J Am Coll Nutr 25:1–11
Cardozo KHM, Guaratini T, Barros MP, Falcão VR, Tonon AP, Lopes NP, Campos S, Torres MA, Souza AO, Colepicolo P et al (2007) Metabolites from algae with economical impact. Comp Biochem Physiol C: Toxicol Pharmacol 146:60–78
Carlucci MJ, Pujol CA, Ciancia M, Noseda MD, Matulewicz MC, Damonte EB, Cerezo AS (1997) Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: correlation between structure and biological activity. Int J Biol Macromol 20:97–105
Carthew P (2002) Safety of carrageenan in foods. Environ Health Perspect 110:A176
Carvalho MDT, Harada LM, Gidlund M, Ketelhuth DFJ, Boschcov P, Quintao ECR (2002) Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: an investigation on the role of natural chylomicrons in atherosclerosis. J Cell Biochem 84:309–323
Cérantola S, Breton F, Ar Gall E, Deslandes E (2006) Co-occurrence and antioxidant activities of fucol and fucophlorethol classes of polymeric phenols in Fucus spiralis. Bot Mar 49:347–351
Cha SH, Ahn GN, Heo SJ, Kim KN, Lee KW, Song CB, Cho SK, Jeon YJ (2006) Screening of extracts from marine green and brown algae in Jeju for potential marine angiotensin-I converting enzyme (ACE) inhibitory activity. J Korean Soc Food Sci Nutr 35:307–314
Chapman VJ (1970) Seaweeds and their uses, 2nd edn. Methuen, London, 304 pp
Chen H-M, Zheng L, Yan X-J (2005) The preparation and bioactivity research of agaro-oligosaccharides. Food Technol Biotechnol 43:29–36
Chernomorsky S, Segelman A, Poretz RD (1999) Effect of dietary chlorophyll derivatives on mutagenesis and tumor cell growth. Tera Carc Mut 19:313–322
Chevolot L, Foucault A, Chaubet F, Kervarec N, Sinquin C, Fisher AM, Boisson-Vidal C (1999) Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity. Carbohydr Res 319:154–165
Cho SH, Kang SE, Cho JY, Kim AR, Park SM, Hong YK, Ahn DH (2007) The antioxidant properties of brown seaweed (Sargassum siliquastrum) extracts. J Med Food 10:479–485
Choi YS, Hong SR, Lee YM, Song KW, Park MH, Nam YS (1999) Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin–alginate sponge. Biomaterials 20:409–417
Chopin T, Gallant T, Davison I (1995) Phosphorus and nitrogen nutrition in Chondrus crispus (Rhodophyta): effects on total phosphorus and nitrogen content, carrageenan production, and photosynthetic pigments and metabolism. J Phycol 31:283–293
Chopin T, Sharp G, Belyea E, Semple R, Jones D (1999) Open-water aquaculture of the red alga Chondrus crispus in Prince Edward Island, Canada. Hydrobiologia 398/399:417–425
Chronakis IS, Galatanu AN, Nylander T, Lindman B (2000) The behaviour of protein preparations from blue-green algae (Spirulina platensis strain Pacifica) at the air/water interface. Colloid Surface Physicochem Eng Aspect 173:181–192
Cloughley G, Burbridge E, Kraan S, Guiry MD, Smyth PPA (2008) Iodine uptake and efflux by macroalgae. 11th International Conference on Applied Phycology, Galway, Ireland, p 81
Connan S, Goulard F, Stiger V, Deslandes E, Ar Gall E (2004) Interspecific and temporal variation in phlorotannin levels in an assemblage of brown algae. Bot Mar 47:410–416
Connan S, Delisle F, Deslandes E, Ar Gall E (2006) Intra-thallus phlorotannin content and antioxidant activity in Phaeophyceae of temperate waters. Bot Mar 49:39–46
Constantinides P, Cairns A, Werner A (1954) Antilipemic activity of sulfated polysaccharides. Arch Int Pharmacodyn Thér 99:334–345
Cornish ML, Garbary DJ (2010) Antioxidants from macroalgae: potential applications in human health and nutrition. Algae 25:000–000. doi:10.4490/algae.2010.25.4.000
Craigie JS (2010) Seaweed extract stimuli in plant science and agriculture. J Appl Phycol. doi:10.1007/z10811-010-9560-4
Cruz-Uribe O, Cheney DP, Rorrer GL (2007) Comparison of TNT removal from seawater by three marine macroalgae. Chemosphere 67:1469–1476
Dannhardt G, Kiefer W (2001) Cyclooxygenase inhibitors—current status and future prospects. Eur J Med Chem 36:109–126
Darias J, Rovirosa J, San Martin A, Diaz AR, Dorta E, Cueto M (2001) Furoplocamioids A-C, novel polyhalogenated furanoid monoterpenes from Plocamium cartilagineum. J Nat Prod 64:1383–1387
Dawczynski C, Schubert R, Jahreis G (2007) Amino acids, fatty acids, and dietary fibre in edible seaweed products. Food Chem 103:891–899
Dembitsky VM, Rozentsvet OA (1990) Phospholipid composition of some marine red algae. Phytochemistry 29:3149–3152
Dembitsky VM, Srebnik M (2002) Natural halogenated fatty acids: their analogues and derivatives. Prog Lipid Res 41:315–367
Dembitsky VM, Rozentsvet OA, Pechenkina EE (1990) Glycolipids, phospholipids and fatty-acids of brown-algae species. Phytochemistry 29:3417–3421
Dembitsky VM, Pechenkinashubina EE, Rozentsvet OA (1991) Glycolipids and fatty-acids of some seaweeds and marine grasses from the Black Sea. Phytochemistry 30:2279–2283
Deville C, Damas J, Forget P, Dandrifosse G, Peulen O (2004) Laminarin in the dietary fibre concept. J Sci Food Agric 84:1030–1038
Deville C, Gharbi M, Dandrifosse G, Peulen O (2007) Study on the effects of laminarin, a polysaccharide from seaweed, on gut characteristics. J Sci Food Agric 87:1717–1725
Dierick N, Ovyn A, De Smet S (2009) Effect of feeding intact brown seaweed Ascophyllum nodosum on some digestive parameters and on iodine content in edible tissues in pigs. J Sci Food Agric 89:584–594
Dietrich CP, Farias GGM, de Abreu LRD, Leite EL, da Silva LF, Nader HB (1995) A new approach for the characterization of polysaccharides from algae: presence of four main acidic polysaccharides in three species of the class Phaeophyceae. Plant Sci 108:143–153
Doh-ura K, Kuge T, Uomoto M, Nishizawa K, Kawasaki Y, Iha M (2007) Prophylactic effect of dietary seaweed fucoidan against enteral prion infection. Antimicrob Agents Chemother 51:2274–2277
Doi K, Tsuji K (1998) Dietary fibers: basics and critics. Asakura Shoten, Tokyo, 426 pp (in Japanese)
Douady D, Rousseau B, Caron L (1994) Fucoxanthin-chlorophyll a/c light-harvesting complexes of Laminaria saccharina: partial amino acid sequences and arrangement in thylakoid membranes. Biochemistry 33:3165–3170
Doyle JW, Roth TP, Smith RM, Li YQ, Dunn RM (1996) Effect of calcium alginate on cellular wound healing processes modeled in vitro. J Biomed Mater Res 32:561–568
Dubber D, Harder T (2008) Extracts of Ceramium rubrum, Mastocarpus stellatus and Laminaria digitata inhibit growth of marine and fish pathogenic bacteria at ecologically realistic concentrations. Aquaculture 274:196–200
Dumelod BD, Ramirez RPB, Tiangson CLP, Barrios EB, Panlasigui LN (1999) Carbohydrate availability of arroz caldo with lambda-carrageenan. Int J Food Sci Nutr 50:283–289
Durcan J, Cave R, Tyrrell L, McGovern, Stengel DB (2010) Arsenic levels in selected red, green and brown macroalgae from Western Ireland. XX Seaweed Symposium, p 121
Durig J, Bruhn T, Zurborn KH, Gutensohn K, Bruhn HD, Beress L (1997) Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85:479–491
Dworjanyn SA, Pirozzi I, Liu W (2007) The effect of the addition of algae feeding stimulants to artificial diets for the sea urchin Tripneustes gratilla. Aquaculture 273:624–633
European Advisory Services (EAS) (2008) Marketing food supplements, fortified and functional foods in Europe. Legislation and practice 2008, 250 pp
EAS (2009) Regulation 1170/2009 amending Directive 2002/46/EC and Regulation 1925/2006 as regards the lists of vitamin and minerals and their forms that can be added to foods, including food supplements. http://www.eas.eu/Legislation.aspx?download=56, accessed 6 April 2010
Ellouali M, Boissonvidal C, Durand P, Jozefonvicz J (1993) Antitumor-activity of low-molecular-weight fucans extracted from brown seaweed Ascophyllum nodosum. Anticancer Res 13:2011–2019
Ennamany R, Saboureau D, Mekideche N, Creppy EE (1998) SECMA 1 (R), a mitogenic hexapeptide from Ulva algeae modulates the production of proteoglycans and glycosaminoglycans in human foreskin fibroblast. Hum Exp Toxicol 17:18–22
Enoki T, Sagawa H, Tominaga T, Nishiyama E, Komyama N, Sakai T, Yu FG, Ikai K, Kato I (2003) Drugs, foods or drinks with the use of algae-derived physiologically active substances. US Patent 0,105,029
Ergün S, Soyutürk M, Güroy B, Güroy D, Merrifield D (2008) Influence of Ulva meal on growth, feed utilization, and body composition of juvenile Nile tilapia (Oreochromis ániloticus) at two levels of dietary lipid. Aquac Int 17:355–361
EU (2008) Kommisionens forordning (EF) Nr. 629/2008, af 2. juli 2008, om ændring af forordning (EF) nr. 1881/2006 om fastsættelse af grænseværdier for bestemte forurenende stoffer i fødevarer. Den Europæiske Unions Tidende, pp 6–9 (in Danish)
European Commission (1997) Novel Food Catalogue. http://ec.europa.eu/food/food/biotechnology/novelfood/nfnetweb/mod_search/index.cfm on December 14 2010
Fan D, Hodges DM, Zhang J, Kirby CW, Ji X, Locke SJ, Critchley AT, Prithiviraj B (2011) Commercial extract of the brown seaweed Ascophyllum nodosum enhances phenolic antioxidant content of spinach (Spinacia oleracea L.) which protects Caenorhabditis elegans against oxidative and thermal stress. Food Chem 124:195–202
FAO (2008) FAO statistics. http://wwwfaoorg/figis/servlet/static?dom=root&xml=aquaculture/indexxml, accessed 2 February 2009
Farvin KHS, Holdt SL, Jacobsen C (2010) Phenolic composition and in vitro antioxidant activities of selected species of seaweeds from Danish coast. 101st American Oil Chemists Society Annual Meeting and Expo, Phoenix, Arizona. May 16–19
Faulkner DJ (2001) Marine natural products. Nat Prod Rep 18:1–49
Fernandez LE, Valiente OG, Mainardi V, Bello JL, Velez H, Rosado A (1989) Isolation and characterization of an antitumor active agar-type polysaccharide of Gracilaria dominguensis. Carbohydr Res 190:77–83
Fleurence J (1999) Seaweed proteins: biochemical, nutritional aspects and potential uses. Trends Food Sci Technol 10:25–28
Fleurence J (2004) Seaweed proteins. In: Yada RY (ed) Proteins in food processing. Woodhead Publishing, Cambridge, pp 197–213
Fleurence J, LeCoeur C, Mabeau S, Maurice M, Landrein A (1995) Comparison of different extractive procedures for proteins from the edible seaweeds Ulva rigida and Ulva rotundata. J Appl Phycol 7:577–582
Fleury N, Lahaye M (1991) Chemical and physicochemical characterization of fibers from Laminaria digitata (Kombu Breton)—a physiological approach. J Sci Food Agric 55:389–400
Flodin C, Helidoniotis F, Whitfield FB (1999) Seasonal variation in bromophenol content and bromoperoxidase activity in Ulva lactuca. Phytochemistry 51:135–138
Foster GG, Hodgson AN (1998) Consumption and apparent dry matter digestibility of six intertidal macroalgae by Turbo sarmaticus (Mollusca: Vetigastropoda: Turbinidae). Aquaculture 167:211–227
Foti MC (2007) Antioxidant properties of phenols. J Pharm Pharmacol 59:1673–1685
Francesconi KA, Edmonds JS (1996) Arsenic and marine organisms. Adv Inorg Chem 44:147–189
Freile-Pelegrín Y, Morales JL (2004) Antibacterial activity in marine algae from the coast of Yucatan, Mexico. Bot Mar 47:140–146
Freile-Pelegrín Y, Robledo D (1997) Effects of season on the agar content and chemical characteristics of Gracilaria cornea from Yucatan, Mexico. Bot Mar 40:285–290
FSAI (2010) http://www.fsai.ie/legislation/food_legislation/novel_foods/application_procedure.html, accessed July 2010
Fujiwara-Arasaki T, Mino N, Kuroda M (1984) The protein value in human nutrition of edible marine algae in Japan. Hydrobiologia 116/117:513–516
Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR (1992) A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem 35:3007–3011
Funahashi H, Imai T, Tanaka Y, Tsukamura K, Hayakawa Y, Kikumori T, Mase T, Itoh T, Nishikawa M, Hayashi H et al (1999) Wakame seaweed suppresses the proliferation of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Jpn J Cancer Res 90:922–927
Funahashi H, Imai T, Mase T, Sekiya M, Yokoi K, Hayashi H, Shibata A, Hayashi T, Nishikawa M, Suda N et al (2001) Seaweed prevents breast cancer? Jpn J Cancer Res 92:483–487
Gahan DA, Lynch MB, Callan JJ, O’Sullivan JT, O’Doherty JV (2009) Performance of weanling piglets offered low-, medium- or high-lactose diets supplemented with a seaweed extract from Laminaria spp. Animal 3:24–31
Galland-Irmouli AV, Fleurence J, Lamghari R, Luçon M, Rouxel C, Barbaroux O, Bronowicki JP, Villaume C, Guéant JL (1999) Nutritional value of proteins from edible seaweed Palmaria palmata (dulse). J Nutr Biochem 10:353–359
Ganesan P, Kumar CS, Bhaskar N (2008) Antioxidant properties of methanol extract and its solvent fractions obtained from selected Indian red seaweeds. Bioresour Technol 99:2717–2723
Garbisa S, Sartor L, Biggin S, Salvato B, Benelli R, Albini A (2001) Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 91:822–832
Gardiner GE, Campbell AJ, O’Doherty JV, Pierce E, Lynch PB, Leonard FC, Stanton C, Ross RP, Lawlor PG (2008) Effect of Ascophyllum nodosum extract on growth performance, digestibility, carcass characteristics and selected intestinal microflora populations of grower-finisher pigs. Anim Feed Sci Technol 141:259–273
Geiszinger A, Goessler W, Pedersen SN, Francesconi KA (2001) Arsenic biotransformation by the brown macroalga Fucus serratus. Environ Toxicol Chem 20:2255–2262
Gessner F (1971) Wasserpermeabilität und Photosynthese bei marinen Algen. Bot Mar 14:29–31
Ghosh T, Chattopadhyay K, Marschall M, Karmakar P, Mandal P, Ray B (2009) Focus on antivirally active sulfated polysaccharides: from structure–activity analysis to clinical evaluation. Glycobiology 19:2–15
Ginzberg A, Cohen M, Sod-Moriah UA, Shany S, Rosenshtrauch A, Arad S (2000) Chickens fed with biomass of the red microalga Porphyridium sp. have reduced blood cholesterol level and modified fatty acid composition in egg yolk. J Appl Phycol 12:325–330
Glyantsev S, Annaev A, Savvina TV (1993) Morphological basis for selecting composition and structure of biologically active compounds based on sodium alginate for wound treatment. Byull Eksp Biol Med 115:65–67
Goemar (2010) http://www.goemar.fr, accessed 5 June 2010
Granert C, Raud J, Waage A, Lindquist L (1999) Effects of polysaccharide fucoidin on cerebrospinal fluid interleukin-1 and tumor necrosis factor alpha in pneumococcal meningitis in the rabbit. Infect Immun 67:2071–2074
Gravett RB (2000) The effect of Ascophyllum nodosum on immune function, performance, and carcass characteristics of sheep and cattle. Master’s thesis, Graduate Faculty of Texas Tech University, pp 1–86
Greger M, Malm T, Kautsky L (2007) Heavy metal transfer from composted macroalgae to crops. Eur J Agron 26:257–265
Gruenwald J (2008) http://www.entrepreneur.com/tradejournals/article/189971352.html, accessed 8 January 2010
Hammerstrom K, Dethier MN, Duggins DO (1998) Rapid phlorotannin induction and relaxation in five Washington kelps. Mar Ecol Prog Ser 165:263–305
Han JG, Syed AQ, Kwon M, Ha JH, Lee HY (2008) Antioxident, immunomodulatory and anticancer activity of fucoidan isolated from Fucus vesiculosus. J Biotechnol 136:571
Haug A, Jensen A (1954) Seasonal variation in the chemical composition of Alaria esculenta, Laminaria saccharina, Laminaria hyperborea and Laminaria digitata from Northern Norway, Norwegian Institute of Seaweed Research. Akademisk Trykningssentral, Blindern, Norway. Report 4, pp 1–14
Haug A, Larsen B (1957) Carotene content of seaweed and seaweed meal. Norwegian Institute of Seaweed Research. Akademisk Trykningssentral, Blindern, Norway. Report 16, pp 1–19
Haug A, Larsen B (1958) Brunfarging av tangmel og tangekstrakter [The formation of brown coloured substances in seaweed and seaweed extracts]. Norwegian Institute of Seaweed Research. NTH Trykk, Norway. Report 22, pp 1–18
Haugan JA, Liaaen-Jensen S (1989) Algal carotenoids.43. Improved isolation procedure for fucoxanthin. Phytochemistry 28:2797–2798
Haugan JA, Liaaen-Jensen S (1994) Algal carotenoids.54. Carotenoids of brown-algae (Phaeophyceae). Biochem Syst Ecol 22:31–41
Hawkins WW, Leonard VG (1963) Antithrombic activity of carrageenan in human blood. Can J Physiol Biochem 41:1325–1327
Hawkins WW, Yaphe W (1965) Carrageenan as a dietary constituent for rat—faecal excretion nitrogen absorption and growth. Can J Biochem 43:479–484
Hawkins WW, Leonard VG, Maxwell JE, Rastogi KS (1962) A study of the prolonged intake of small amounts of EDTA on the utilization of low dietary levels of calcium and iron by the rat. Can J Physiol Biochem 40:391
Hayashi L, Yokoya NS, Ostini S, Pereira RTL, Braga ES, Oliveira EC (2008) Nutrients removed by Kappaphycus alvarezii (Rhodophyta, Solieriaceae) in integrated cultivation with fishes in re-circulating water. Aquaculture 277:185–191
Heller L (2009) Functional foods: what they mean around the world. http://www.nutraingredients-usa.com/Industry/Functional-foods-What-they-mean-around-the-world, accessed July 2010
Hellio C, De La Broise D, Dufosse L, Le Gal Y, Bourgougnon N (2001) Inhibition of marine bacteria by extracts of macroalgae: potential use for environmentally friendly antifouling paints. Mar Environ Res 52:231–247
Hemmingson J, Falshaw R, Furneaux R, Thompson K (2006) Structure and antiviral activity of the galactofucan sulfates extracted from Undaria pinnatifida (Phaeophyta). J Appl Phycol 18:185–193
Hennequart F (2007) Seaweed applications in human health/nutrition: the example of algal extracts as functional ingredients in novel beverages. 4th International Symposium Health and Sea, Granville, France. http://www.sante-mer.com/pdf_dwnld/O17_Presentation_H_HENNEQUART.pdf, accessed 26 October 2010
Heo SJ, Jeon YJ (2009) Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage. J Photochem Photobiol B 65:101–107
Heo SJ, Park EJ, Lee KW, Jeon YJ (2005) Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour Technol 96:1613–1623
Herbreteau F, Coiffard LJM, Derrien A, De Roeck-Holtzhauer Y (1997) The fatty acid composition of five species of macroalgae. Bot Mar 40:25–27
Hoebler C, Guillon F, Darcy-Vrillon B, Vaugelade P, Lahaye M, Worthington E, Duee PH, Barry JL (2000) Supplementation of pig diet with algal fibre changes the chemical and physicochemical characteristics of digesta. J Sci Food Agric 80:1357–1364
Hoffmane R, Paper DH, Donaldson J, Alban S, Franz G (1995) Characterization of a laminarin sulfate which inhibits basic fibroblast growth-factor binding and endothelial-cell proliferation. J Cell Sci 108:3591–3598
Holdt SL (2009) Nutrient reduction in aquaculture waste by macroalgae production. PhD dissertation, University of Southern Denmark, 80 pp
Hori K, Ikegami S, Miyazawa K, Ito K (1988) Mitogenic and antineoplastic isoagglutinins from the red alga Solieria robusta. Phytochemistry 27:2063–2067
Hori K, Matsubara K, Miyazawa K (2000) Primary structures of two hemagglutinins from the marine red alga, Hypnea japonica. Biochim Biophys Acta Gen Subj 147:226–236
Hori K, Sato Y, Ito K, Fujiwara Y, Iwamoto Y, Makino H, Kawakubo A (2007) Strict specificity for high-mannose type N-glycans and primary structure of a red alga Eucheuma serra lectin. Glycobiology 17:479–491
Horn SJ (2000) Bioenergy from brown seaweeds. PhD dissertation, Department of Biotechnology, Norwegian University of Science and Technology, NTNU, Norway, 82 pp
Hosokawa M, Wanezaki S, Miyauchi K, Kunihara H, Kohno H, Kawabata J, Odashima S, Takahashi K (1999) Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HIL-60. Food Sci Technol Res 5:243–246
Houghton JD (1996) Haems and bilins. In: Houghton JD, Hendry GAF (eds) Natural food colorants, 2nd edn. Blackie (Chapman and Hall), Glasgow, pp 157–196
Houston MC (2005) Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog Cardiovasc Dis 47:396–449
Hu JF, Geng MY, Zhang JT, Jiang HD (2001) An in vitro study of the structure–activity relationships of sulfated polysaccharide from brown algae to its antioxidant effect. J Asian Nat Prod Res 3:353–358
Huang HL, Wang BG (2004) Antioxidant capacity and lipophilic content of seaweeds collected from the Qingdao coastline. J Agric Food Chem 52:4993–4997
Ichikawa S, Kamoshida M, Hanaoka K, Hamano M, Maitani T, Kaise T (2006) Decrease of arsenic in edible brown algae Hijikia fusiforme by the cooking process. Appl Organomet Chem 20:585–590
Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T (2003) Effect of Undaria pinnatifida (wakame) on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 30:44–48
Iliopoulou D, Roussis V, Pannecouque C, De Clercq E, Vagias C (2002) Halogenated sesquiterpenes from the red alga Laurencia obtusa. Tetrahedron 58:6749–6755
Indergaard M, Minsaas J (1991) Seaweed resources in Europe: uses and potential. In: Guiry MD, Blunden G (eds) Animal and human nutrition. Wiley, Chichester, pp 21–64
Iqbal M, Flick-Smith H, McCauley JW (2000) Interactions of bovine viral diarrhoea virus glycoprotein E-rns with cell surface glycosaminoglycans. J Gen Virol 81:451–459
Ishihara K, Murata M, Kaneniwa M, Saito H, Shinohara K, Maeda-Yamamoto M (1998) Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. Biosci Biotechnol Biochem 62:1412–1415
Ishihara K, Murata M, Kaneniwa M, Saito H, Komatsu W, Shinohara K (2000) Purification of stearidonic acid (18: 4(n-3)) and hexadecatetraenoic acid (16: 4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography. Biosci Biotechnol Biochem 64:2454–2457
Ito K, Tsuchida Y (1972) The effect of algal polysaccharides on depressing of plasma cholesterol level in rats. Proceedings of the7th International Seaweed Symposium, pp 451–455
Je J-Y, Park PJ, Kim EK, Park JS, Yoon HD, Kim KR, Ahn CB (2009) Antioxidant activity of enzymatic extracts from the brown seaweed Undaria pinnatifida by electron spin resonance spectroscopy. LWT Food Sci Technol 42:874–878
Jenkins DJA, Wolever TMS, Leeds AR, Gassull MA, Haisman P, Dilawari J, Goff DV, Metz GL, Alberti KGMM (1978) Dietary fibers, fiber analogs, and glucose-tolerance—importance of viscosity. Br Med J 1:1392–1394
Jensen A (1956) Component sugars of some common brown algae. Norwegian Institute of Seaweed Research, Akademisk Trykningssentral, Blindern, Oslo. Report 9, pp 1–8
Jensen A (1960) Produksjon av tangmel. Norwegian Institute of Seaweed Research, N.T.H. TRYKK. Report 24, pp 1–23
Jensen A (1966) Carotenoids of Norwegian brown seaweeds and of seaweed meals. Norwegian Institute of Seaweed Research, TAPIR. Report 31, pp 1–138
Jensen A (1969a) Tocopherol content of seaweed and seaweed meal. 2. Individual, diurnal and seasonal variations in some Fucaceae. J Sci Food Agric 20:454–458
Jensen A (1969b) Tocopherol content of seaweed and seaweed meal. 3. Influence of processing and storage on content of tocopherols, carotenoids and ascorbic acid in seawood meal. J Sci Food Agric 20:622–626
Jensen A, Haug A (1956) Geographical and seasonal variation in the chemical composition of Laminaria hyperborea and Laminaria digitata from the Norwegian coast. Norwegian Institute of Seaweed Research, Akademisk Trykningssentral, Blindern, Oslo. Report 14, pp 1–8
Jensen A, Nebb H, Sæter EA (1968) The value of Norwegian seaweed meal as a mineral supplement for dairy cows. Norwegian Institute of Seaweed Research, TAPIR. Report 32, pp 1–35
Jeon Y-J, Athukorala Y, Lee J (2005) Characterization of agarose product from agar using DMSO. Algae 20:61–67
Johnson CR, Mann KH (1986) The importance of plant defence abilities to the structure of subtidal seaweed communities: the kelp Laminaria longicruris de la Pylaie survives grazing by the snail Lacuna vincta (Montagu) at high population densities. J Exp Mar Biol Ecol 97:231–267
Jones AL, Harwood JL (1992) Lipid composition of the brown algae Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry 31:3397–3403
Joseph J, Niggemann B, Zaenker KS, Entschladen F (2002) The neurotransmitter γ-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res 62:6467–6469
Kaeffer B, Benard C, Lahaye M, Blottiere HM, Cherbut C (1999) Biological properties of ulvan, a new source of green seaweed sulfated polysaccharides, on cultured normal and cancerous colonic epithelial tells. Planta Med 65:527–531
Kalt W, McDonald JE, Donner H (2000) Anthocyanins, phenolics, and antioxidant capacity of processed lowbush blueberry products. J Food Sci 65:390–393
Kanazawa K, Ozaki Y, Hashimoto T, Das SK, Matsushita S, Hirano M, Okada T, Komoto A, Mori N, Nakatsuka M (2008) Commercial-scale preparation of biofunctional fucoxanthin from waste parts of brown sea algae Laminalia japonica. Food Sci Technol Res 14:573–582
Kang K, Park Y, Hwang HJ, Kim SH, Lee JG, Shin HC (2003) Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors. Arch Pharm Res 26:286–293
Katayama S, Ohshita J, Sugaya K, Hirano M, Momose Y, Yamamura S (1998) New medicinal treatment for severe gingivostomatitis. Int J Mol Med 2:675–679
Kawakubo AL, Makino H, Ohnishi J, Hirohara H, Hori K (1997) The marine red alga Eucheuma serra J. Agardh, a high yielding source of two isolectins. J Appl Phycol 9:331–338
Kawakubo A, Makino H, Ohnishi J, Hirohara H, Hori K (1999) Occurrence of highly yielded lectins homologous within the genus Eucheuma. J Appl Phycol 11:149–156
Khan MNA, Cho JY, Lee MC, Kang JY, Park NG, Fujii H, Hong YK (2007) Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida. J Agric Food Chem 55:6984–6988
Khan MNA, Suk-Choi J, Lee MC, Kim E, Nam TJ, Fujii H, Hong YK (2008) Anti-inflammatory activities of methanol extracts from various seaweed species. J Environ Biol 29:465–469
Khotimchenko SV (1991) Fatty-acid composition of 7 Sargassum species. Phytochemistry 30:2639–2641
Khotimchenko SV (2003) The fatty acid composition of glycolipids of marine macrophytes. Russ J Mar Biol 29:126–128
Khotimchenko SV (2005) Lipids from the marine alga Gracilaria verrucosa. Chem Nat Compd 41:285–288
Khotimchenko SV, Levchenko EV (1997) Lipids of the red alga Gracilaria verrucosa (Huds.) Papenf. Bot Mar 40:541–545
Khotimchenko YS, Kovalev VV, Savchenko OV, Ziganshina OA (2001) Physical–chemical properties, physiological activity, and usage of alginates, the polysaccharides of brown algae. Russ J Mar Biol 27:53–64
Kim IH, Lee JH (2008) Antimicrobial activities against methicillin-resistant Staphylococcus aureus from macroalgae. J Ind Eng Chem 14:568–572
Kim MK, JP D, Thomas JC, Giraud G (1996) Seasonal variations of triacylglycerols and fatty acids in Fucus serratus. Phytochemistry 43:49–55
Kimura Y, Watanabe K, Okuda H (1996) Effects of soluble sodium alginate on cholesterol excretion and glucose tolerance in rats. J Ethnopharmacol 54:47–54
Kindness G, Williamson FB, Long WF (1979) Effect of polyanetholesulphonic acid and xylan sulphate on antithrombin III activity. Biochem Biophys Res Commun 13:1062–1068
Kiriyama S, Okazaki Y, Yoshida A (1969) Hypocholesterolemic effect of polysaccharides and polysaccharide-rich foodstuffs in cholesterol-fed rats. J Nutr 97:382–388
Klinkenberg-Knol EC, Festen HP, Meuwissen SG (1995) Pharmacological management of gastro-oesophageal reflux disease. Drugs 49:495–710
Knott MG, Mkwananzi H, Arendse CE, Hendricks DT, Bolton JJ, Beukes DR (2005) Plocoralides A-C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza. Phytochemistry 66:1108–1112
Korver O, Kühn MC, Richardson DP (2008) The functional food dossier; Building solid health claims. Practical industrial guide. Foodlink Forum, Bennekom, the Netherlands, 185 pp
Kotake-Nara E, Kushiro M, Zhang H, Sugawara T, Miyashita K, Nagao A (2001) Carotenoids affect proliferation of human prostate cancer cells. J Nutr 131:3303–3306
Kumar CS, Ganesan P, Bhaskar N (2008a) In vitro antioxidant activities of three selected brown seaweeds of India. Food Chem 107:707–713
Kumar CS, Ganesan P, Suresh PV, Bhaskar N (2008b) Seaweeds as a source of nutritionally beneficial compounds—a review. J Food Sci Technol 45:1–13
Kumar KS, Ganesane K, Rao PVS (2008c) Antioxidant potential of solvent extracts of Kappaphycus alvarezii (Doty) Doty—an edible seaweed. Food Chem 107:289–295
Kuznetsova TA, Krylova NV, Besednova NN, Vasiléva VN, Zviagintseva TN, Krashevskii SV, Eliakova LA (1994) The effect of translam on the natural resistance indices of the irradiated organism. Radiats Biol Radioecol 34:236–239
Kylin H (1913) Zur Biochemie der Meeresalgen. Hoppe-Seyler’s Z Physiol Chem 83:171–197
Lahaye M (1991) Marine-algae as sources of fibers—determination of soluble and insoluble dietary fiber contents in some sea vegetables. J Sci Food Agric 54:587–594
Lahaye M (1998) NMR spectroscopic characterisation of oligosaccharides from two Ulva rigida ulvan samples (Ulvales, Chlorophyta) degraded by a lyase. Carbohydr Res 314:1–12
Lahaye M, Kaeffer B (1997) Seaweed dietary fibres: structure, physico-chemical and biological properties relevant to intestinal physiology. Sci Aliment 17:563–584
Lahaye M, Ray B (1996) Cell-wall polysaccharides from the marine green alga Ulva rigida (Ulvales, Chlorophyta)—NMR analysis of ulvan oligosaccharides. Carbohydr Res 283:161–173
Lahaye M, Robic A (2007) Structure and functional properties of ulvan, a polysaccharide from green seaweeds. Biomacromolecules 8:1765–1774
Lahaye M, Michel C, Barry JL (1993) Chemical, physicochemical and in vitro fermentation characteristics of dietary-fibers from Palmaria palmata (L.) Kuntze. Food Chem 47:29–36
Lahaye M, Inizan F, Vigouroux J (1998) NMR analysis of the chemical structure of ulvan and of ulvan–boron complex formation. Carbohydr Polym 36:239–249
Lahaye M, Rondeau-Mouro C, Deniaud E, Buleon A (2003) Solid-state 13C NMR spectroscopy studies of xylans in the cell wall of Palmaria palmata (L. Kuntze, Rhodophyta). Carbohydr Res 338:1559–1569
Lam C, Stang A, Harder T (2008) Planktonic bacteria and fungi are selectively eliminated by exposure to marine macroalgae in close proximity. FEMS Microbiol Ecol 63:283–291
Lamare MD, Wing SR (2001) Calorific content of New Zealand marine macrophytes. NZ J Mar Freshwat Res 35:335–341
Lamela M, Anca J, Villar R, Otero J, Calleja JM (1989) Hypoglycemic activity of several seaweed extracts. J Ethnopharmacol 27:35–43
Larsen B, Haug A (1958) The influence of habitat on the chemical composition of Ascophyllum nodosum (L.) Le Jol.-reprint of report 20. Norwegian Institute of Seaweed Research. Trondheim, Norway, pp 29–38
Lasky LA (1995) Selectin–carbohydrate interactions and the initiation of the inflammatory response. Annu Rev Biochem 64:113–139
Le Tutour B (1990) Antioxidative activities of algal extracts, synergistic effect with vitamin E. Phytochemistry 29:3759–3765
Le Tutour B, Benslimane F, MPe G, Saadan B, Quemeneur F (1998) Antioxidant and pro-oxidant activities of the brown algae, Laminaria digitata, Himanthalia elongata, Fucus vesiculosus, Fucus serratus and Ascophyllum nodosum. J Appl Phycol 10:121–129
Lee JB, Hayashi K, Hashimoto M, Nakano T, Hayashi T (2004) Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu). Chem Pharm Bull 52:1091–1094
Li F, Tian TC, Shi YC (1995) Study on anti virus effect of fucoidan in vitro. J Norman Bethune Univ Med Sci 21:255–257
Li N, Zhang QB, Song JM (2005) Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats. Food Chem Toxicol 43:421–426
Li K, Li XM, Ji NY, Wang BG (2007) Natural bromophenols from the marine red alga Polysiphonia urceolata (Rhodomelaceae): structural elucidation and DPPH radical-scavenging activity. Bioorg Med Chem 15:6627–6631
Li B, Lu F, Wei XJ, Zhao RX (2008a) Fucoidan: structure and bioactivity. Molecules 13:1671–1695
Li Y, Qian ZJ, Le QT, Kim MM, Kim SK (2008b) Bioactive phloroglucinol derivatives isolated from an edible marine brown alga, Ecklonia cava. J Biotechnol 136:578
Li Y, Qian ZJ, Ryu B, Lee SH, Kim MM, Kim SK (2009) Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava. Bioorg Med Chem 17:1963–1973
Liao WR, Lin JY, Shieh WY, Jeng WL, Huang R (2003) Antibiotic activity of lectins from marine algae against marine vibrios. J Ind Microbiol Biotechnol 30:433–439
Lim SN, Cheung PCK, Ooi VEC, Ang PO (2002) Evaluation of antioxidative activity of extracts from a brown seaweed, Sargassum siliquastrum. J Agric Food Chem 50:3862–3866
Liu RM, Bignon J, Haroun-Bouhedja F, Bittoun P, Vassy J, Fermandjian S, Wdzieczak-Bakala J, Boisson-Vidal C (2005) Inhibitory effect of fucoidan on the adhesion of adenocarcinoma cells to fibronectin. Anticancer Res 25:2129–2133
Lobban CS, Harrison PJ (1994) Seaweed ecology and physiology. Cambridge University Press, Cambridge, 384 pp
Lourenço R, Camilo ME (2002) Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp 17:262–270
Lüder UH, Clayton MN (2004) Induction of phlorotannins in the brown macroalga Ecklonia radiata (Laminariales, Phaeophyta) in response to simulated herbivory—the first microscopic study. Planta 218:928–937
Lüning (2008) Integrated macroalgae-oyster aquaculture on a north sea island: seasonal productivity of the brown alga Laminaria saccharina and the red algae Palmaria palmata; Solieria chordalis, Gracilaria vermiculophylla, and the use of these seaweeds in human nutrition or as raw material for the cosmetics industry. 11th International Conference on Applied Phycology, Galway, Ireland. June 22–27
Luescher-Mattli M (2003) Algae, a possible source for new drugs in the treatment of HIV and other viral diseases. Curr Med Chem 2:219–225
Mabeau S, Fleurence J (1993) Seaweed in food products: biochemical and nutritional aspects. Trends Food Sci Technol 4:103–107
MacArtain P, Gill CIR, Brooks M, Campbell R, Rowland IR (2007) Nutritional value of edible seaweeds. Nutr Rev 65:535–543
Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K (2005) Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 332:392–397
Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita K (2008a) Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac J Clin Nutr 17:196–199
Maeda H, Hosokawa M, Sashima T, Miyashita K (2008b) Antiobesity effect of fucoxanthin from edible seaweeds and its multibiological functions. ACS Symp Ser 993:376–388
Mai K, Mercer JP, Donlon J (1994) Comparative studies on the nutrition of two species of abalone, Haliotis tuberculata L. and Haliotis discus Hannai Ino. II. Amino acid composition of abalone and six species of macroalgae with an assessment of their nutritional-value. Aquaculture 128:115–130
Maliakal PP, Coville PF, Wanwimolruk S (2001) Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats. J Pharm Pharmacol 53:569–577
Mandal P, Mateu CG, Chattopadhyay K, Pujol CA, Damonte EB, Ray B (2007) Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica. Antiviral Chem Chemother 18:153–162
Marais MF, Joseleau JP (2001) A fucoidan fraction from Ascophyllum nodosum. Carbohydr Res 336:155–159
Marinho-Soriano E, Fonseca PC, Carneiro MAA, Moreira WSC (2006) Seasonal variation in the chemical composition of two tropical seaweeds. Bioresour Technol 97:2402–2406
Marinova (2010) Nutraceuticals from Maritech extracts. http://www.marinova.com.au/Nutraceuticals.html on December 13 2010
Marsham S, Scott GW, Tobin ML (2007) Comparison of nutritive chemistry of a range of temperate seaweeds. Food Chem 100:1331–1336
Martino AD, Douady D, Quinet-Szely M, Rousseau B, Crépineau F, Apt K, Caron L (2004) The light-harvesting antenna of brown algae. Highly homologous proteins encoded by a multigene family. Eur J Biochem 267:5540–5549
Maruyama H, Tamauchi H, Hashimoto M, Nakano T (2003) Antitumor activity and immune response of Mekabu fucoidan extracted from sporophyll of Undaria pinnatifida. In Vivo 17:245–249
Maruyama H, Tamauchi H, Iizuka M, Nakano T (2006) The role of NK cells in antitumor activity of dietary fucoidan from Undoria pinnotifida sporophylls (Mekabu). Planta Med 72:1415–1417
Maruyama H, Tanaka M, Hashimoto M, Inoue M, Sasahara T (2007) The suppressive effect of Mekabu fucoidan on an attachment of Cryptosporidium parvum oocysts to the intestinal epithelial cells in neonatal mice. Life Sci 80:775–781
Matsubara K, Sumi H, Hori K (1996) Platelet aggregation is inhibited by phycolectins. Experientia 52:540–543
Matsubara K, Xue C, Zhao X, Mori M, Sugawara T, Hirata T (2005) Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells. Int J Mol Med 15:695–699
Mayer AMS, Hamann MT (2004) Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Mar Biotechnol 6:37–52
Mayer AMS, Rodríguez AD, Berlinck RGS, Hamann MT (2007) Marine pharmacology in 2003–4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Comp Biochem Physiol C 145:553–581
McHugh DJ (1987) Production and utilization of products from commercial seaweeds. FAO Fisheries Technical Paper No. 288, pp 1–189
McHugh DJ (2003) A guide to the seaweed industry. FAO Fish Tech Pap 441, Rome, Italy, 105 pp
Mehta SK, Gaur JP (2005) Use of algae for removing heavy metal ions from wastewater: progress and prospects. Crit Rev Biotechnol 25:113–152
Miao HQ, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, Vlodavsky I (1999) Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 83:424–431
Michel C, Macfarlane GT (1996) Digestive fates of soluble polysaccharides from marine macroalgae: involvement of the colonic microflora and physiological consequences for the host. J Appl Bacteriol 80:349–369
Michel C, Lahaye M, Bonnet C, Mabeau S, Barry JL (1996) In vitro fermentation by human faecal bacteria of total and purified dietary fibres from brown seaweeds. Br J Nutr 75:263–280
Miki W (1991) Biological functions and activities of animal carotenoids. Pure Appl Chem 63:141–146
Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23:381–393
Miraglio AM (2009) Phospholipids: structure plus functionality. http://www foodproductdesign com/articles/2006/03/phospholipids-structure-plus-functionality.aspx, accessed 5 June 2010
Mishra VK, Temelli F, Ooraikul B, Shacklock PF, Craigie JS (1993) Lipids of the red alga, Palmaria palmata. Bot Mar 36:169–174
Miyashita H, Hosokawa M (2008) Beneficial health effects of seaweed carotenoid, fucoxanthin. In: Barrow C, Shahidi F (eds) Marine nutraceuticals and functional foods. CRC, Boca Raton, pp 297–320
Mochizuki H, Takido J, Oda H, Yokogoshi H (1999) Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 63:1984–1987
Morgan K, Wright J, Simpson F (1980) Review of chemical constituents of the red alga Palmaria palmata (dulse). Econ Bot 34:27–50
Mori J, Matsunaga T, Takahashi S, Hasegawa C, Saito H (2003) Inhibitory activity on lipid peroxidation of extracts from marine brown alga. Phytother Res 17:549–551
Mori T, O’Keefe BR, Sowder RC, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW, McMahon JB et al (2005) Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J Biol Chem 280:9345–9353
Morrissey J, Kraan S, Guiry MD (2001) A guide to commercially important seaweeds on the Irish coast. Bord Iascaigh Mhara, Dublin, 66 pp
Morse ANC (1991) GABA-mimetic peptides from marine algae and cyanobacteria as potential diagnostic and therapeutic agents. In: Thompson MF, Sarojini R, Nagabhushanam R (eds) Bioactive compounds from marine organisms. Oxford & IBH Publishing, New Delhi, pp 167–172
Mouradi-Givernaud A, Givernaud T, Morvan H, Cosson J (1992) Agar from Gelidium latifolium (Rhodophyceae, Gelidiales)—biochemical composition and seasonal variations. Bot Mar 35:153–159
Mouritsen OG (2009) Tang-grøntsager fra havet. Nyt Nordisk Forlag, Arnold Busck, Copenhagen, 284 pp (in Danish)
Munda IM (1977) Differences in amino acid composition of estuarine and marine fucoids. Aquat Bot 3:273–280
Murata M, Nakazoe J (2001) Production and use of marine algae in Japan. Jpn Agr Res Q 35:281–290
Murata M, Ishihara K, Saito H (1999) Hepatic fatty acid oxidation enzyme activities are stimulated in rats fed the brown seaweed, Undaria pinnatifida (wakame). J Nutr 129:146–151
Murata M, Sano Y, Ishihara K, Uchida M (2002) Dietary fish oil and Undaria pinnatifida (wakame) synergistically decrease rat serum and liver triacylglycerol. J Nutr 132:742–747
Müssig K (2009) Iodine-induced toxic effects due to seaweed consumption. In: Preedy VR, Burrow GN, Watson R (eds) Comprehensive handbook of iodine. Elsevier, New York, pp 897–908
Mustafa MG, Wakamatsu S, Takeda TA, Umino T, Nakagawa H (1995) Effects of algae meal as feed additive on growth, feed efficiency, and body composition in red sea bream. Fish Sci 61:25–28
Nabors LOB (2004) Alternative sweeteners. Agro Food Industry Hi-Tech 15:39–41
Nagaoka M, Shibata H, Kimura-Takagi I, Hashimoto S, Kimura K, Makino T, Aiyama R, Ueyama S, Yokokura T (1999) Structural study of fucoidan from Cladosiphon okamuranus Tokida. Glycoconj J 16:19–26
Nagaoka M, Shibata H, Kimura I, Hashimoto S (2003) Oligosaccharide derivatives and process for producing the same. United States Patent No. 6,645,940
Nagayama K, Shibata T, Fujimoto K, Honjo T, Nakamura T (2003) Algicidal effect of phlorotannins from the brown alga Ecklonia kurome on red tide microalgae. Aquaculture 218:601–611
Nakagawa H, Kasahara S (1986) Effect of Ulva meal supplement to diet on the lipid metabolism of red sea bream. Bull Jpn Soc Sci Fish 52:1887–1893
Nakagawa H, Umino T, Tasaka Y (1997) Usefulness of Ascophyllum meal as a feed additive for red sea bream, Pagrus major. Aquaculture 151:275–281
Nakamura T, Nagayama K, Uchida K, Tanaka R (1996) Antioxidant activity of phlorotannins isolated from the brown alga Eisenia bicyclis. Fish Sci 62:923–926
Nakazawa Y, Sashima T, Hosokawa M, Miyashita K (2009) Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines. J Funct Foods 1:88–97
Narayan B, Miyashita K, Hosakawa M (2006) Physiological effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—a review. Food Rev Int 22:291–307
Nasu T, Fukuda Y, Nagahira K, Kawashima H, Noguchi C, Nakanishi T (1997) Fucoidin, a potent inhibitor of L-selectin function, reduces contact hypersensitivity reaction in mice. Immunol Lett 59:47–51
Nishide E, Uchida H (2003) Effects of Ulva powder on the ingestion and excretion of cholesterol in rats. In: Chapman ARO, Anderson RJ, Vreeland VJ, Davison IR (eds) Proceedings of the 17th International Seaweed Symposium. Oxford University Press, Oxford, pp 165–168
Nishide E, Anzai H, Uchida N (1993) Effects of alginates on the ingestion and excretion of cholesterol in the rat. J Appl Phycol 5:207–211
Nishino T, Nishioka C, Ura H, Nagumo T (1994) Isolation and partial characterization of a novel amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan. Carbohydr Res 255:213–224
Nisizawa K (2002) Seaweed Kaiso, bountiful harvest from the seas. Sustenance for health and well-being by preventing common life-style related diseases. Kochi University, Kochi, 106 pp
Noa M, Mas R, Carbajal D, Valdes S (2000) Effect of D-002 on acetic acid-induced colitis in rats at single and repeated doses. Pharmacol Res 41:391–395
Noda H (1993) Health benefits and nutritional properties of nori. J Appl Phycol 5:255–258
Okuzumi J, Takahashi T, Yamane T, Kitao Y, Inagake M, Ohya K, Nishino H, Tanaka Y (1993) Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N′-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis. Cancer Lett 68:159–168
Omata M, Matsui N, Inomata N, Ohno T (1997) Protective effects of polysaccharide fucoidin on myocardial ischemia–reperfusion injury in rats. J Cardiovasc Pharmacol 30:717–724
Ortiz J, Romero N, Robert P, Araya J, Lopez-Hernández J, Bozzo C, Navarrete E, Osorio A, Rios A (2006) Dietary fiber, amino acid, fatty acid and tocopherol contents of the edible seaweeds Ulva lactuca and Durvillaea antarctica. Food Chem 99:98–104
Ostergaard C, Yieng-Kow RV, Benfield T, Frimodt-Moller N, Espersen F, Lundgren JD (2000) Inhibition of leukocyte entry into the brain by the selectin blocker fucoidin decreases interleukin-1 (IL-1) levels but increases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits. Infect Immun 68:3153–3157
Panlasigui LN, Baello OQ, Dimatangal JM, Dumelod BD (2003) Blood cholesterol and lipid-lowering effects of carrageenan on human volunteers. Asia Pac J Clin Nutr 12:209–214
Paradossi G, Cavalieri F, Chiessi E (2002) A conformational study on the algal polysaccharide ulvan. Macromolecules 35:6404–6411
Park PJ, Heo SJ, Park EJ, Kim SK, Byun HG, Jeon BT, Jeon YJ (2005) Reactive oxygen scavenging effect of enzymatic extracts from Sargassum thunbergii. J Agric Food Chem 53:6666–6672
Parsons AF (1996) Recent developments in kainoid amino acid chemistry. Tetrahedron 52:4149–4174
Pavia H, Åberg P (1996) Spatial variation in polyphenolic content of Ascophyllum nodosum (Fucales, Phaeophyta). Hydrobiologia 326/327:199–203
Pavia H, Cervin G, Lindgren A, Åberg P (1997) Effects of UV-B radiation and simulated herbivory on phlorotannins in the brown alga Ascophyllum nodosum. Mar Ecol Prog Ser 157:139–146
Pedersen M, Collen J, Abrahamsson K, Ekdahl A (1996) Production of halocarbons from seaweeds: an oxidative stress reaction? Sci Mar 60:257–263
Percival E, McDowell RH (1990) Algal polysaccharides. In: Dey PM (ed) Methods in plant biochemistry, volume 2: carbohydrates. Academic, London, pp 523–547
Perelló G, Martí-Cid R, Llobet JM, Domingo JL (2008) Effects of various cooking processes on the concentrations of arsenic, cadmium, mercury, and lead in foods. J Agric Food Chem 56:11262–11269
Plaza M, Cifuentes A, Ibáñez E (2008) In the search of new functional food ingredients from algae. Trends Food Sci Technol 19:31–39
Plouguerne E, Hellio C, Deslandes E, Veron B, Stiger-Pouvreau V (2008) Anti-microfouling activities in extracts of two invasive algae: Grateloupia turuturu and Sargassum muticum. Bot Mar 51:202–208
Population Council (2008) Trial shows anti-HIV microbicide is safe, but does not prove it effective. http://www.popcouncil.org/mediacenter/newsreleases/2008_CarraguardResults.asp on December 12 2010
Qi HM, Zhang QB, Zhao TT, Chen R, Zhang H, Niu XZ, Li Z (2005a) Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro. Int J Biol Macromol 37:195–199
Qi HM, Zhao TT, Zhang QB, Li Z, Zhao ZQ, Xing R (2005b) Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm (Chlorophyta). J Appl Phycol 17:527–534
Ragan MA, Jensen A (1978) Quantitative studies on brown algal phenols. II. Seasonal variation in polyphenol content of Ascophyllum nodosum (L.) Le Jol. and Fucus vesiculosus (L.). J Exp Mar Biol Ecol 34:245–258
Ramsey UP, Bird CJ, Shacklock PF, Laycock MV, Wright JL (1994) Kainic acid and 1′-hydroxykainic acid from Palmariales. Nat Toxins 2:286–292
Rasmussen RS, Morrissey MT (2007) Marine biotechnology for production of food ingredients. In: Taylor SL (ed) Advances in food and nutrition research, vol 52. Elsevier, New York, pp 237–292
Reckitt and Colman Products Ltd (1999) Formulations for the treatment of gastro-oesophageal reflux. US Patent No. 6,348,502
Reilly P, O’Doherty JV, Pierce KM, Callan JJ, O’Sullivan JT, Sweeney T (2008) The effects of seaweed extract inclusion on gut morphology, selected intestinal microbiota, nutrient digestibility, volatile fatty acid concentrations and the immune status of the weaned pig. Animal 2:1465–1473
Renn DW, Noda H, Amano H, Nishino T, Nishizana K (1994a) Antihypertensive and antihyperlipidemic effects of funoran. Fish Sci 60:423–427
Renn DW, Noda H, Amano H, Nishino T, Nishizana K (1994b) Study on hypertensive and antihyperlipidemic effect of marine algae. Fish Sci 60:83–88
Reynolds JEF, Prasad AB (1982) Martindale the extra pharmacopoeia. 28th Pharmaceutical Press, London, 735 pp
Riccardi BA, Fahrenbach MJ (1965) Effect of guar gum and pectin on serum and liver lipids of cholesterol-fed rats. Proc Soc Exp Biol Med 124:749–752
Rioux LE, Turgeon SL, Beaulieu M (2007) Characterization of polysaccharides extracted from brown seaweeds. Carbohydr Polym 69:530–537
Robertson WV, Schwartz B (1953) Ascorbic acid and the formation of collagen. J Biol Chem 201:689–696
Robledo D, Freile-Pelegrín Y (1997) Chemical and mineral composition of six potentially edible seaweed species of Yucatan. Bot Mar 40:301–306
Rocha de Souza M, Marques C, Guerra Dore C, Ferreira da Silva F, Oliveira Rocha H, Leite E (2007) Antioxidant activities of sulfated polysaccharides from brown and red seaweeds. J Appl Phycol 19:153–160
Rodrigueza MRC, Montaño MNE (2007) Bioremediation potential of three carrageenophytes cultivated in tanks with seawater from fish farms. J Appl Phycol 19:755–762
Ronnberg O, Adjers K, Ruokolahti C, Bondestam M (1990) Fucus vesiculosus as an indicator of heavy metal availability in a fish farm recipient in the northern Baltic Sea. Mar Pollut Bull 21:388–392
Rorrer GL, Yoo HD, Huang YM, Hayden C, Gerwick WH (1997) Production of hydroxy fatty acids by cell suspension cultures of the marine brown alga Laminaria saccharina. Phytochemistry 46:871–877
Rupérez P (2002) Mineral content of edible marine seaweeds. Food Chem 79:23–26
Rupérez P, Saura-Calixto F (2001) Dietary fibre and physicochemical properties of edible Spanish seaweeds. Eur Food Res Technol 212:349–354
Ruperez P, Ahrazem O, Leal JA (2002) Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem 50:840–845
Sailler B, Glombitza KW (1999) Phlorethols and fucophlorethols from the brown alga Cystophora retroflexa. Phytochemistry 50:869–881
Sampath-Wiley P, Neefus CD, Jahnke LS (2008) Seasonal effects of sun exposure and emersion on intertidal seaweed physiology: fluctuations in antioxidant contents, photosynthetic pigments and photosynthetic efficiency in the red alga Porphyra umbilicalis Kützing (Rhodophyta, Bangiales). J Exp Mar Biol Ecol 361:83–91
Sanchez-Machado DI, Lopez-Cervantes J, Lopez-Hernandez J, Paseiro-Losada P (2004a) Fatty acids, total lipid, protein and ash contents of processed edible seaweeds. Food Chem 85:439–444
Sanchez-Machado DI, Lopez-Hernandez J, Paseiro-Losada P, Lopez-Cervantes J (2004b) An HPLC method for the quantification of sterols in edible seaweeds. Biomed Chromatogr 18:183–190
Sandau E, Sandau P, Pulz O, Zimmermann M (1996) Heavy metal sorption by marine algae and algae by-products. Acta Biotechnol 16:103–119
Sathivel A, Raghavendran HRB, Srinivasan P, Devaki T (2008) Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on d-galactosamine induced hepatitis in rats. Food Chem Toxicol 46:3262–3267
Sato M, Hosokawa T, Yamaguchi T, Nakano T, Muramoto K, Kahara T, Funayama K, Kobayashi A, Nakano T (2002) Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J Agric Food Chem 50:6245–6252
Satoh K, Nakagawa H, Kasahara S (1987) Effect of Ulva meal supplementation on disease resistance of red sea bream. Nippon Suisan Gakkaishi 53:1115–1120
Savitskaya IM (1986) Trial of a local hemostatic with alginate base. Klin Khirurgiya 3:39–40
Schaeffer DJ, Krylov VS (2000) Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicol Environ Saf 45:208–227
Segal HC, Hunt BJ, Gilding K (1998) The effects of alginate and non-alginate wound dressings on blood coagulation and platelet activation. J Biomater Appl 12:249–257
Sekar S, Chandramohan M (2008) Phycobiliproteins as a commodity: trends in applied research, patents and commercialization. J Appl Phycol 20:113–136
Sen AK, Das AK, Banerji N, Siddhanta AK, Mody KH, Ramavat BK, Chauhan VD, Vedasiromoni JR, Ganguly DK (1994) A new sulfated polysaccharide with potent blood anti-coagulant activity from the red seaweed Grateloupia Indica. Int J Biol Macromol 16:279–280
Shanmugam M, Mody KH (2000) Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents. Curr Sci 79:1672–1683
Sheth BB (1967) Alginate containing antacid compositions. US Patent No. 3,326,755
Shinagawa A, Shiomi K, Yamanaka H, Kicuchi T (1983) Selective determination of inorganic arsenic(III), (V) and organic arsenic in marine organisms. Bull Jpn Soc Sci Fish 49:75–78
Shiu CT, Lee TM (2005) Ultraviolet-B-induced oxidative stress and responses of the ascorbate–glutathione cycle in a marine macroalga Ulva fasciata. J Exp Bot 56:2851–2865
Sieburth JM, Conover JT (1965) Sargassum tannin, an antibiotic which retards fouling. Nature 208:52–53
Simpson FJ, Shacklock PF (1979) The cultivation of Chondrus crispus. Effect of temperature on growth and carrageenan production. Bot Mar 22:295–298
Siriwardhana N, Lee KW, Kim SH, Ha JW, Jeon YJ (2003) Antioxidant activity of Hizikia fusiformis on reactive oxygen species scavenging and lipid peroxidation inhibition. Food Sci Technol Int 9:339–346
Siriwardhana N, Lee KW, Kim SH, Ha JH, Park GT, Jeon YJ (2004) Lipid peroxidation inhibitory effects of Hizikia fusiformis methanolic extract on fish oil and linoleic acid. Food Sci Technol Int 10:65–72
Skoler-Karpoff S, Ramjee G, Ahmed K, Altini L, Plagianos MG, Friedland B, Govender S, Kock AD, Cassim N, Palanee T et al (2008) Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. Lancet 372:1977–1987
Slezka IE, Miroshichenko VA, Vostrikova OG, Ziganshina OA (1998) Applications of bioactive compounds from marine organisms in atherosclerosis prophylaxis in children, new biomedical technologies using bioactive additives. Proceedings of All Russian Conference. IMKVL Siberian Branch, Ross Akad Med Nauk, Vladivostok, pp 90–94
Smit AJ (2004) Medicinal and pharmaceutical uses of seaweed natural products: a review. J Appl Phycol 16:245–262
Smith DG, Young EG (1953) On the nitrogenous constituents of Fucus vesiculosus. J Biol Chem 205:849–858
Soler-Vila A, Coughlan S, Guiry MD, Kraan S (2009) The red alga Porphyra dioica as a fish-feed ingredient for rainbow trout (Oncorhynchus mykiss): effects on growth, feed efficiency and carcass composition. J Appl Phycol 21:617–624
Sørensen HO (2009) Marine phospholipids. Int Aqua Feed 12:14–15
Sæter EA, Jensen A (1957) Forsøk med tangmel som tilskuddsfôr til sau [Experiments with seaweed meal as supplement to rations for sheep—summary in English]. Norwegian Institute of Seaweed Research. Akademisk Trykningssentral, Blinder, Oslo. Report 17, pp 1–30
Spieler R (2002) Seaweed compound’s anti-HIV efficacy will be tested in southern Africa. Lancet 359:1675
Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. BBA-Mol Basis Disease 1740:101–107
Stahl W, Ale-Agha N, Polidori MC (2002) Non-antioxidant properties of carotenoids. Biol Chem 383:553–558
Suetsuna K (1998a) Purification and identification of angiotensin I converting enzyme inhibitors from the red alga Porphyra yezoensis. J Mar Biotechnol 6:163–167
Suetsuna K (1998b) Separation and identification of angiotensin I-converting enzyme inhibitory peptides from peptic digest of Hizikia fusiformis protein. Nippon Suisan Gakkaishi 64:862–866
Suetsuna K, Maekawa K, Chen JR (2004) Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J Nutr Biochem 15:267–272
Sugahara T, Ohama Y, Fukuda A, Hayashi M, Kawakubo A, Kato K (2001) The cytotoxic effect of Eucheuma serra agglutinin (ESA) on cancer cells and its application to molecular probe for drug delivery system using lipid vesicles. Cytotechnology 36:93–99
Sugawara T, Baskaran V, Tsuzuki W, Nagao A (2002) Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice. J Nutr 132:946–951
Suzuki M, Daitoh M, Vairappan CS, Abe T, Masuda M (2002) Brominated metabolites from an Okinawan Laurencia intricate. Phytochemistry 60:861–867
Swinyard EA, Pathak MA (1985) Surface-acting drugs. In: Gilman AG, Goodman LS, Rall TW (eds) The pharmacological basis of therapeutics, 7th edn. Macmillan, New York, pp 946–958
Takahashi N, Ojika M, Dogasaki C, Nisizawa M, Fukuoka H, Sahara H, Sato N, Mori M, Kikuchi K (2000) Substance isolated from the kelp rhizoid identified as l-tryptophan shows high inhibition of breast cancer. Gan To Kagaku Ryoho 27:251–255
Tasende MG (2000) Fatty acid and sterol composition of gametophytes and sporophytes of Chondrus crispus (Gigartinaceae, Rhodophyta). Sci Mar 64:421–426
Terada A, Hara H, Mitsuoka T (1995) Effect of dietary alginate on the faecal microbiota and faecal metabolic activity in humans. Microb Ecol Health Dis 8:259–266
Tititudorancea (2009) http://www tititudorancea com/z/nutrition_facts_undaria_spp_seaweed_wakame_raw htm, accessed 2 February 2009
Tobacman JK (2001) Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environ Health Perspect 109:983–994
Torsdottir I, Alpsten M, Holm G, Sandberg AS, Tolli J (1991) A small dose of soluble alginate-fiber affects postprandial glycemia and gastric-emptying in humans with diabetes. J Nutr 121:795–799
Tseng CK (2001) Algal biotechnology industries and research activities in China. J Appl Phycol 13:375–380
Tsuchiya Y (1969) Comparative hypocholesterolemic activities of marine algae. Proceeding of the International Seaweed Symposium 6:747–757
Urbano MG, Goñi I (2002) Bioavailability of nutrients in rats fed on edible seaweeds, nori (Porphyra tenera) and wakame (Undaria pinnatifida), as a source of dietary fibre. Food Chem 76:281–286
Usov AI, Smirnova GP, Klochkova NG (2001) Polysaccharides of algae: 55. Polysaccharide composition of several brown algae from Kamchatka. Russ J Bioorgan Chem 27:395–399
Vadas S, Wright WA, Beal BF (2004) Biomass and productivity of intertidal rockweeds (Ascophyllum nodosum LeJolis) in Cobscook Bay. Northeastern Naturalist 11:123–142
Vairappan CS, Suzuki M, Abe T, Masuda M (2001) Halogenated metabolites with antibacterial activity from the Okinawan Laurencia species. Phytochemistry 58:517–523
Valente LMP, Gouveia A, Rema P, Matos J, Gomes EF, Pinto IS (2006) Evaluation of three seaweeds Gracilaria bursa-pastoris, Ulva rigida and Gracilaria cornea as dietary ingredients in European sea bass (Dicentrarchus labrax) juveniles. Aquaculture 252:85–91
van de Velde F, Lourenco ND, Pinheiro HM, Bakker M (2002) Carrageenan: a food-grade and biocompatible support for immobilisation techniques. Adv Synth Catal 344:815–835
van Netten C, Hoption Cann SA, Morley DR, van Netten JP (2000) Elemental and radioactive analysis of commercially available seaweed. Sci Total Environ 255:169–175
Vaugelade P, Hoebler C, Bernard F, Guillon F, Lahaye M, Duee PH, Darcy-Vrillon B (2000) Non-starch polysaccharides extracted from seaweed can modulate intestinal absorption of glucose and insulin response in the pig. Reprod Nutr Dev 40:33–47
Ventura MR, Castañón JIR (1998) The nutritive value of seaweed (Ulva lactuca) for goats. Small Rumin Res 29:325–327
Verdrengh M, Erlandsson-Harris H, Tarkowski A (2000) Role of selectins in experimental Staphylococcus aureus-induced arthritis. Eur J Immunol 30:1606–1613
Vlieghe P, Clerc T, Pannecouque C, Witvrouw M, De Clercq E, Salles JP, Kraus JL (2002) Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities. J Med Chem 45:1275–1283
Voet D, Voet J, Pratt CW (1999) Fundamentals of biochemistry. Wiley, New York, 1095 pp
von Elbe JH, Schwartz SJ (1996) Colorants. In: Fennema OR (ed) Food chemistry. Marcel Dekker, New York, pp 651–722
Wahbeh MI (1997) Amino acid and fatty acid profiles of four species of macroalgae from Aqaba and their suitability for use in fish diets. Aquaculture 159:101–109
Wang WT, Zhou JH, Xing ST (1994) Immunomodulating action of marine algae sulfated polysaccharides on normal and immunosuppressed mice. Chin J Pharm Toxicol 8:199–202
Wang GC, Sun HB, Fan X, Tseng CK (2002) Large-scale isolation and purification of R-phycoerythrin from red alga Palmaria palmata using the expanded bed adsorption method. Acta Bot Sin 44:541–546
Wang Y, Han F, Hu B, Li JB, Yu WG (2006) In vivo prebiotic properties of alginate oligosaccharides prepared through enzymatic hydrolysis of alginate. Nutr Res 26:597–603
Wang J, Zhang QB, Zhang ZS, Li Z (2008) Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. Int J Biol Macromol 42:127–132
Washington N, Denton G (1995) Effect of alginate and alginate–cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux. J Pharm Pharmacol 47:879–882
Weinberger F (2007) Pathogen-induced defense and innate immunity in macroalgae. Biol Bull 213:290–302
Wen X, Peng CL, Zhou HC, Lin ZF, Lin GZ, Chen SW, Li P (2006) Nutritional composition and assessment of Gracilaria lemaneiformis Bory. J Integr Plant Biol 48:1047–1053
Whittaker MH, Frankos VH, Wolterbeek AMP, Waalkens-Berendsen DH (2000) Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence. Am J Med 109:600–601
Wikipedia (2010) www.wikipedia.com, accessed 25 June 2010
Witvrouw M, DeClercq E (1997) Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. Gen Pharmacol Vasc Syst 29:497–511
Wong KH, Cheung PCK (2000) Nutritional evaluation of some subtropical red and green seaweeds. Part I—proximate composition, amino acid profiles and some physico-chemical properties. Food Chem 71:475–482
Wong K, Cheung PC (2001a) Influence of drying treatment on three Sargassum species. 2. Protein extractability, in vitro protein digestibility and amino acid profile of protein concentrates. J Appl Phycol 13:51–58
Wong K, Cheung PC (2001b) Influence of drying treatment on three Sargassum species. 1. Proximate composition, amino acid profile and some physico-chemical properties. J Appl Phycol 13:43–50
Wong KH, Cheung PCK (2001c) Nutritional evaluation of some subtropical red and green seaweeds. Part II. In vitro protein digestibility and amino acid profiles of protein concentrates. Food Chem 72:11–17
Wright AD, Goclik E, Konig GM (2003) Three new sesquiterpenes from the red alga Laurencia perforata. J Nat Prod 66:435–437
Wu XW, Yang ML, Huang XL, Yan J, Luo Q (2003) Effect of fucoidan on splenic lymphocyte apoptosis induced by radiation. Chin J Radiol Med Prot 23:43–50
Xu WJ, Liao XJ, Xu SH, Diao JZ, Du B, Zhou XL, Pan SS (2008) Isolation, structure determination, and synthesis of galaxamide, a rare cytotoxic cyclic pentapeptide from a marine algae Galaxaura filamentosa. Org Lett 10:4569–4572
Xue CH, Chen L, Li ZJ, Cai YP, Lin H, Fang Y (2004) Antioxidative activities of low molecular fucoidans from kelp Laminaria japonica. Dev Food Sci 42:139–145
Yamamoto I, Takahashi M, Tamura E, Maruyama H, Mori H (1984) Antitumor-activity of edible marine-algae—effect of crude fucoidan fractions prepared from edible brown seaweeds against L-1210 leukemia. Hydrobiologia 116:145–148
Yan XJ, Chuda Y, Suzuki M, Nagata T (1999) Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed. Biosci Biotechnol Biochem 63:605–607
Yan XJ, Zheng L, Chen HM, Lin W, Zhang WW (2004) Enriched accumulation and biotransformation of selenium in the edible seaweed Laminaria japonica. J Agric Food Chem 52:6460–6464
Yang XL, Sun JY, Xu HN (1995) An experimental study on immunoregulatory effect of fucoidan. Chin J Mar Drugs 14:909–913
Yasui A, Tsutsumi C, Toda S (1978) Selective determination of inorganic arsenic(III), (V) and organic arsenic in biological materials by solvent extraction atomic absorption spectrophotometry. Agric Biol Chem 42:2139–2145
Ye H, Wang K, Zhou C, Liu J, Zeng X (2008) Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum. Food Chem 111:428–432
Ying P, Shakibaei M, Patankar MS, Clavijo P, Beavis RC, Clark GF, Frevert U (1997) The malaria circumsporozoite protein: Interaction of the conserved regions I and II-plus with heparin-like oligosaccharides in heparan sulfate. Exp Parasitol 85:168–182
Yone Y, Furuichi M, Urano K (1986) Effects of wakame Undaria pinnatifida and Ascophyllum nodosum on absorption of dietary nutrients, and blood sugar and plasma free amino-N levels of red sea bream. Bull Jpn Soc Sci Fish 52:1817–1819
Young EG, Smith DG (1958) Amino acids, peptides, and proteins of Irish moss, Chondrus crispus. J Biol Chem 233:406–410
Yuan YV (2008) Marine algal constituents. In: Barrow C, Shahidi F (eds) Marine neutraceuticals and functional foods. CRC, Boca Raton, pp 297–320
Yuan YV, Walsh NA (2006) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds. Food Chem Toxicol 44:1144–1150
Yuan YV, Carrington MF, Walsh NA (2005) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. Food Chem Toxicol 43:1073–1081
Zaragoza MC, Lopez D, Saiz MP, Poquet M, Perez J, Puig-Parellada P, Marmol F, Simonetti P, Gardana C, Lerat Y et al. (2008) Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts. J Agric Food Chem 56:7773–7780
Zee S (1991) Body weight loss with the aid of alginic acid. Arc Intern Med 3-4:113–114
Zeitlin L, Whaley KJ, Hegarty TA, Moench TR, Cone RA (1997) Tests of vaginal microbicides in the mouse genital herpes model. Contraception 56:329–335
Zeitoun P, Salmon L, Bouche O, Jolly, D, Thiefin G (1998) Outcome of erosive/ulcerative reflux oesophagitis in 181 consecutive patients 5 years after diagnosis. Ital J Gastroenterol Hepatol 30:470–474
Zhang QB, Li N, Zhou GF, Lu XL, Xu ZH, Li Z (2003) In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice. Pharmacol Res 48:151–155
Zhang JZ, Tiller C, Shen JK, Wang C, Girouard GS, Dennis D, Barrow CJ, Miao MS, Ewart HS (2007) Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosum. Can J Physiol Pharmacol 85:1116–1123
Zhao X, Xue CH, Li BF (2008) Study of antioxidant activities of sulfated polysaccharides from Laminaria japonica. J Appl Phycol 20:431–436
Zhou G, Sheng W, Yao W, Wang C (2006a) Effect of low molecular [lambda]-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu. Pharmacol Res 53:129–134
Zhou Y, Yang HS, Hu HY, Liu Y, Mao YZ, Zhou H, Xu XL, Zhang FS (2006b) Bioremediation potential of the macroalga Gracilaria lemaneiformis (Rhodophyta) integrated into fed fish culture in coastal waters of North China. Aquaculture 252:264–276
Zhuang C, Itoh H, Mizuno T, Ito H (1995) Antitumor active fucoidan from the brown seaweed, Umitoranoo (Sargassum thunbergii). Biosci Biotechnol Biochem 59:563–567
Zou Y, Qian ZJ, Li Y, Kim MM, Lee SH, Kim SK (2008) Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical-mediated oxidative systems. J Biotechnol 136:S579–S580
Zubia M, Payri C, Deslandes E (2008) Alginate, mannitol, phenolic compounds and biological activities of two range-extending brown algae, Sargassum mangarevense and Turbinaria ornata (Phaeophyta: Fucales), from Tahiti (French Polynesia). J Appl Phycol 20:1033–1043
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Holdt, S.L., Kraan, S. Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 23, 543–597 (2011). https://doi.org/10.1007/s10811-010-9632-5
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DOI: https://doi.org/10.1007/s10811-010-9632-5