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Hydroxybutyl chitosan thermo-sensitive hydrogel: a potential drug delivery system

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Abstract

Drug delivery mediated by hydrogel has shown great promise in controlled drug release field. We report here the development of a hydroxybutyl chitosan (HBC) thermo-sensitive gel to deliver doxorubicine hydrochloride (DOX·HCl) for cancer treatment. Concentrated HBC aqueous solution could transform into hydrogel within 30 s after injection under physiological temperature in non-chemical fashion. The properties of the HBC gels including chemical structure, surface morphology, and rheologic properties were studied. Gelation temperature and gelation time of HBC could be adjusted by HBC concentrations. The gel erosion rate in vivo was faster than solubilization rate in vitro. The mild inflammatory response caused by implantation of the hydrogel was acceptable. The DOX·HCl (1 mg/ml) loaded HBC gels displayed slow release rates that were independent of the HBC concentration, and significantly reduced viability of 4T-1 cells compared with the HBC gels after 1 day incubation. These results indicate that thermo-sensitive HBC hydrogels have promising potential as an injectable drug carrier for pharmaceutical applications.

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Acknowledgements

This research was granted by Science and Technology Breakthrough Project (2011GSF12124), National Natural Science Foundation of China (81071274, 81071246), and International Science and Technology Cooperation Project (2011DFA31270).

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Authors and Affiliations

  1. College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, People’s Republic of China

    Qian Qian Wang, Ming Kong, Ya Liu, Xuan Zhou, Chao Feng, Xiao Jie Cheng & Xi Guang Chen

  2. The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266001, Shandong, People’s Republic of China

    Yi An, Jian Li & Shao Yan Jiang

  3. College of Life Science and Bioengineering, Beijing University of Technology, Beijing, 100022, People’s Republic of China

    Jing Jing Li

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  1. Qian Qian Wang
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  2. Ming Kong
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  3. Yi An
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  4. Ya Liu
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  6. Xuan Zhou
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  7. Chao Feng
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  8. Jian Li
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  9. Shao Yan Jiang
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  10. Xiao Jie Cheng
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  11. Xi Guang Chen
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Corresponding authors

Correspondence to Xiao Jie Cheng or Xi Guang Chen.

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Wang, Q.Q., Kong, M., An, Y. et al. Hydroxybutyl chitosan thermo-sensitive hydrogel: a potential drug delivery system. J Mater Sci 48, 5614–5623 (2013). https://doi.org/10.1007/s10853-013-7356-z

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  • DOI: https://doi.org/10.1007/s10853-013-7356-z

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