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In vivo biocompatibility of Mg implants surface modified by nanostructured merwinite/PEO

  • Biomaterials Synthesis and Characterization
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Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Magnesium (Mg) alloys have been suggested as biodegradable bone implant materials due to their good intrinsic biocompatibility and great mechanical properties. Although magnesium has attractive properties as an orthopedic implant material, its quick degradation and low bioactivity may lead to the loss of mechanical integrity of the implant during the bone healing process. In this paper, we endeavor to surmount the abovementioned defects using the surface coating technique. We have recently coated AZ91 magnesium implants with merwinite (Ca3MgSi2O8) through the coupling of plasma electrolytic oxidation (PEO) and electrophoretic deposition method. In this work, we are specifically focused on the in vivo examinations of the coated implants in comparison with the uncoated one. For the in vivo experiment, the rod samples, including the uncoated and merwinite/PEO coated implants, were imbedded into the greater trochanter of rabbits. The results of the in vivo animal test indicated an improvement in biodegradability including slower implant weight loss, reduction in Mg ion released from the coated implants in the blood plasma, lesser release of hydrogen bubbles and an improvement in biocompatibility including an increase in the amount of bone formation and ultimately a mild bone inflammation after the surgery according to the histological images. In summary, proper surface treatment of magnesium implants such as silicate bioactive ceramics may improve their biocompatibility under physiological conditions to making them suitable and applicable for future clinical applications.

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Acknowledgments

The authors are thankful for the contributions of Isfahan University of Technology, Torabinejad Dental Research Center, Oklahoma Center for Advancement of Science and Technology (Grant No. AR131-054 8161), AFOSR (Grant No. FA9550-10-1-0010) and the National Science Foundation (NSF, Grant No. 0933763).

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Authors and Affiliations

  1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran

    Mehdi Razavi & Mohammadhossein Fathi

  2. Dental Materials Research Center, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran

    Mehdi Razavi & Mohammadhossein Fathi

  3. Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran

    Omid Savabi

  4. School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK, 74106, USA

    Mehdi Razavi & Lobat Tayebi

  5. Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27606, USA

    Daryoosh Vashaee

  6. Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53201, USA

    Lobat Tayebi

  7. Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Palo Alto, CA, 94305, USA

    Lobat Tayebi

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  1. Mehdi Razavi
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  2. Mohammadhossein Fathi
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Correspondence to Mehdi Razavi or Lobat Tayebi.

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Razavi, M., Fathi, M., Savabi, O. et al. In vivo biocompatibility of Mg implants surface modified by nanostructured merwinite/PEO. J Mater Sci: Mater Med 26, 184 (2015). https://doi.org/10.1007/s10856-015-5514-3

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