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In vitro study on cytocompatibility and osteogenesis ability of Ti–Cu alloy

  • Biocompatibility Studies
  • Original Research
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Abstract

Titanium implants easily suffer bacteria-related infections in clinic due to their inherent lack of self-protection ability. Therefore, a novel Ti–Cu alloy with good antibacterial activity has been developed as a new kind of implant material. This study focuses on a systematic evaluation of both cytocompatibility and osteogenesis activity of the Ti–Cu alloy in vitro. It was revealed that an addition of 5% Cu into pure Ti would not cause any negative effect on osteoblasts adhesion, proliferation and apoptosis cultured with Ti–Cu alloy. In addition, Ti–Cu alloy could significantly promote the osteogenic differentiation of MG 63 cells by upregulating the osteogenesis-related gene expressions including alkaline phosphatase (ALP), Collagen I (Colla I), osteopontin (OPN) and osteocalcin (OCN). These promising results suggest that the Ti–Cu alloy has great potential to be used as a multi-functional titanium implant for clinical applications.

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Acknowledgements

This work was financially supported by the National Key Research and Development Program of China (2018YFC1106600, 2016YFC1100600), National Natural Science Foundation (Nos. 51631009, 51811530320, 81572113), Innovation Fund Project of Institute of Metal Research, Chinese Academy of Sciences (2017-ZD01) and Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences (174321KYSB2018000) and Shenzhen Science and Technology Research Funding (JCYJ20160608153641020).

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Authors and Affiliations

  1. Northeastern University, 3-11 Wenhua Road, 110819, Shenyang, China

    Rui Liu

  2. Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, 110016, Shenyang, China

    Rui Liu, Zheng Ma, Sharafadeen Kunle Kolawole, Ling Ren & Ke Yang

  3. Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, 518055, Shenzhen, China

    Lilan Zeng & Ying Zhao

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  1. Rui Liu
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  2. Zheng Ma
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Correspondence to Ying Zhao, Ling Ren or Ke Yang.

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Liu, R., Ma, Z., Kunle Kolawole, S. et al. In vitro study on cytocompatibility and osteogenesis ability of Ti–Cu alloy. J Mater Sci: Mater Med 30, 75 (2019). https://doi.org/10.1007/s10856-019-6277-z

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