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Recurrent Salmonella typhi Infection and Autoimmunity in a Young Boy with Complete IL-12 Receptor β1 Deficiency

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Authors and Affiliations

  1. Department of Pediatrics, Allergy Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Ankur Kumar Jindal, Deepti Suri, Sandesh Guleria, Amit Rawat & Surjit Singh

  2. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Sumit Garg & Amanjit Bal

  3. Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, Paris, France

    Jean-Laurent Casanova & Jacinta Bustamante

  4. Imagine Institute, Paris Descartes University, Paris, France

    Jean-Laurent Casanova & Jacinta Bustamante

  5. St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA

    Jean-Laurent Casanova

  6. Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France

    Jean-Laurent Casanova & Jacinta Bustamante

  7. Howard Hughes Medical Institute, New York, NY, USA

    Jean-Laurent Casanova

  8. Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, Paris, France

    Jacinta Bustamante

Authors
  1. Ankur Kumar Jindal
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  2. Deepti Suri
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  3. Sandesh Guleria
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  4. Amit Rawat
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  5. Sumit Garg
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  6. Amanjit Bal
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  7. Jean-Laurent Casanova
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  8. Jacinta Bustamante
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  9. Surjit Singh
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Correspondence to Deepti Suri.

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Electronic Supplementary Material

Supplementary Figure 1

Colonic biopsy showing features of activity in the form of crypt distortion and crypt loss and chronicity in the form of cryptitis and crypt abscess (A; H&E, 40X), (B; H&E, 100X), (C; H&E, 200X), Negative for acid fast bacilli (D; ZN stain, 1000X) (PNG 7475 kb)

High Resolution Image (TIF 2471 kb)

Supplementary Table 1

Laboratory investigations (DOCX 12 kb)

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Jindal, A.K., Suri, D., Guleria, S. et al. Recurrent Salmonella typhi Infection and Autoimmunity in a Young Boy with Complete IL-12 Receptor β1 Deficiency. J Clin Immunol 39, 358–362 (2019). https://doi.org/10.1007/s10875-019-00637-0

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  • DOI: https://doi.org/10.1007/s10875-019-00637-0

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