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Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters

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Abstract

The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)4Ru4(μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4(μ-H)4][BF4]2 and [(η6-C6H6)4Ru4(μ-H)3(μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4(μ-H)4][PF6]2 is also reported.

Graphical Abstract

The in vitro activity of a series of ruthenium clusters has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines and their activity compared to cisplatin. The triruthenium clusters are very active, while the tetraruthenium clusters do not display significant cytotoxicities.

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Acknowledgement

The authors are grateful to the Fonds National Suisse de la Recherche Scientifique for financial support. A generous loan of ruthenium chloride hydrate from the Johnson Matthey Technology Centre is gratefully acknowledged.

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Author notes

  1. Frédéric Chérioux

    Present address: Laboratoire FEMTO-ST, UMR CNRS 6174, 32 Avenue de l’Observatoire, 25044, Besançon cedex, France

Authors and Affiliations

  1. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009, Neuchâtel, Switzerland

    Bruno Therrien, Frédéric Chérioux, Ludovic Vieille-Petit & Georg Süss-Fink

  2. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland

    Wee Han Ang & Paul J. Dyson

  3. Centre Hospitalier Universitaire Vaudois (CHUV), University Institute of Pathology, 1011, Lausanne, Switzerland

    Lucienne Juillerat-Jeanneret

Authors
  1. Bruno Therrien
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  2. Wee Han Ang
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Correspondence to Georg Süss-Fink or Paul J. Dyson.

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Dedicated to Professor Dieter Fenske on the occasion of his 65th birthday anniversary

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Therrien, B., Ang, W.H., Chérioux, F. et al. Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters. J Clust Sci 18, 741–752 (2007). https://doi.org/10.1007/s10876-007-0140-y

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  • DOI: https://doi.org/10.1007/s10876-007-0140-y

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