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Development of porous ultra high molecular weight polyethylene scaffolds for the fabrication of orbital implant

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Abstract

Porous implants having interconnecting channels allow ingrowth of host connective tissue. Complete implant vascularization reduces the risk of infection, extrusion, and other complications associated with nonintegrated implants. Attempts were made to develop 60% and 70% porous ultra high molecular weight polyethylene (UHMWPE) scaffolds and blocks using sodium chloride as channeling agent, which when dissolved in boiling water leaves behind the interconnecting channels. The average diameter of the pores of 60% and 70% porous scaffolds was found to be approx. 170 µm and 210 µm, respectively. Mechanical characterizations of the scaffolds indicated sufficient strength to be used for orbital implant fabracation. Surface roughness of the scaffolds indicated increase in surface roughness with the increase in porosity. The scaffolds developed were found to be hemocompatible with the human blood. Subsequently, the 70% porous scaffold was dip coated with a solution mixture of sodium carboxy methyl cellulose (SCMC)/polyvinyl alcohol (PVA)/hydroxyapatite (HA) which also showed hemocompatibility. Ciprofloxacin release pattern from the membrane was determined. Finally an orbital implant was fabricated from the 70% porous scaffold.

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Acknowledgment

DRDO ER & IPR Division, New Delhi for partially supporting the work.

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Authors and Affiliations

  1. Materials Science Centre, Indian Institute of Technology, Kharagpur, 721 302, India

    Kunal Pal

  2. School Of BioScience and Engineering, Jadavpur University, Kolkata, 700032, India

    S. Bag & S. Pal

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  1. Kunal Pal
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  2. S. Bag
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  3. S. Pal
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Correspondence to Kunal Pal.

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Pal, K., Bag, S. & Pal, S. Development of porous ultra high molecular weight polyethylene scaffolds for the fabrication of orbital implant. J Porous Mater 15, 53–59 (2008). https://doi.org/10.1007/s10934-006-9051-9

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  • DOI: https://doi.org/10.1007/s10934-006-9051-9

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