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99mTc–meropenem as a potential SPECT imaging probe for tumor hypoxia

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Abstract

Meropenem was successfully radiolabeled with 99mTc in high labeling yield (92 ± 2%) and stability (~6 h). 99mTc–meropenem showed high accumulation in tumor hypoxic tissue (4.193% injected dose/g organ). 99mTc–meropenem showed high ability to differentiate the tumor tissue from inflamed or infected tissues in different mice models as its T/NT ratio ~4 in case of tumor mice model while T/NT ratio ~1 in case of inflamed mice model. So, 99mTc–meropenem showed high selectivity in comparison with FDG-PET and 99mTc-nitroimidazole analogues. Thus, 99mTc–meropenem could be used as a selective potential imaging agent for diagnosis of tumor hypoxia.

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Authors and Affiliations

  1. Radioactive Isotopes and Generator Department, Hot Labs Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    T. M. Sakr

  2. Labeled Compounds Department, Hot Labs Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. A. Motaleb & I. T. Ibrahim

Authors
  1. T. M. Sakr
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  2. M. A. Motaleb
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  3. I. T. Ibrahim
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Correspondence to T. M. Sakr.

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Sakr, T.M., Motaleb, M.A. & Ibrahim, I.T. 99mTc–meropenem as a potential SPECT imaging probe for tumor hypoxia. J Radioanal Nucl Chem 292, 705–710 (2012). https://doi.org/10.1007/s10967-011-1481-4

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  • DOI: https://doi.org/10.1007/s10967-011-1481-4

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