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Production of 47Sc, 67Cu, 68Ga, 105Rh, 177Lu, and 188Re using electron linear accelerator

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Abstract

Radioisotopes used in nuclear medicine (47Sc, 67Cu, 68Ga, 105Rh, 177Lu, and 188Re) were produced by an electron linear accelerator in this study. Neutron irradiation was investigated as an alternative method for producing 105Rh and 177Lu, and the results were compared with those obtained with the electron linear accelerator. All the radioisotopes except for 177Lu were produced efficiently by the electron linear accelerator. Electron linear accelerators were thus demonstrated to show the desired performance for the on-demand production of medical radioisotopes at consuming places such as hospitals.

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Acknowledgements

We are grateful to Mr. K. Itosu and Mr. Y. Ono of Kyoto University for their help in conducting the experiments at LINAC, as well as measurements and analyses. We thank Mr. N. Abe of the Institute for Integrated Radiation and Nuclear Science, Kyoto University (KURNS), for the operation of the LINAC at KURNS. We are also grateful to the members of the LINAC group at KURNS for the arrangement of machine time. We express our gratitude to the members of the research reactor group at KURNS for the preparation and operation in the neutron irradiation at KUR. This study was supported by a grant-in-aid from Kansai Genshiryoku Kondankai (to SS). This study was also supported by grants-in-aid from Japan Society for the Promotion of Science (JSPS KAKENHI Grant Nos. JP18H04150, JP26286076, JP19K22596 to TO, JP16K15580 to SS).

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Authors and Affiliations

  1. Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-nishi, Kumatori, Sennan, Osaka, 590-0494, Japan

    Makoto Inagaki, Shun Sekimoto & Tsutomu Ohtsuki

  2. Graduate School of Engineering, Kyoto University, Kyoto-daigaku-katsura, Nishikyo-ku, Kyoto, 615-8510, Japan

    Wataru Tanaka

  3. Research & Development Group, Hitachi, Ltd., 7-2-1 Ohmika, Hitachi, Ibaraki, 319-1221, Japan

    Takahiro Tadokoro, Yuichiro Ueno & Yuko Kani

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  1. Makoto Inagaki
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  2. Shun Sekimoto
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  3. Wataru Tanaka
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  4. Takahiro Tadokoro
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  5. Yuichiro Ueno
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  6. Yuko Kani
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  7. Tsutomu Ohtsuki
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Correspondence to Makoto Inagaki.

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Inagaki, M., Sekimoto, S., Tanaka, W. et al. Production of 47Sc, 67Cu, 68Ga, 105Rh, 177Lu, and 188Re using electron linear accelerator. J Radioanal Nucl Chem 322, 1703–1709 (2019). https://doi.org/10.1007/s10967-019-06904-z

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  • DOI: https://doi.org/10.1007/s10967-019-06904-z

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