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Thermal characterization of solid lipid nanoparticles containing praziquantel

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Abstract

Solid lipid nanoparticles (SLNs), loaded and unloaded with praziquantel (PRZ-load SLN and PRZ-unload SLN) were prepared by two different procedures: (a) oil-in-water hot microemulsion method, obtaining at 70 °C an optically transparent blend composed of surfactant, co-surfactant, and water; and (b) oil-in-water microemulsion method, dissolving the lipid in an immiscible organic solvent, emulsified in water containing surfactants and co-surfactant, and then evaporated under reduced pressure at 50 °C. The mean diameter, polydispersity index (PdI), and zeta potential were 187 to 665 nm, 0.300 to 0.655, and −25 to −28 mV respectively, depending on the preparation method. The components, binary mixture, SLNs loaded and unloaded with PRZ, and physical mixture were evaluated by differential scanning calorimetry (DSC) and thermogravimetry (TG). The non-isothermal isoconversional Flynn-Wall–Ozawa method was used to determine the kinetic parameters associated with the thermal decomposition of the samples. The experimental data indicated a linear relationship between the apparent activation energy E and the pre-exponential factor A, also called the kinetic compensation effect (KCE), allowing us to determine the stability with respect to the preparation method. Loading with PRZ increased the thermal stability of the SLNs.

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Authors and Affiliations

  1. Faculdade de Ciências Farmacêuticas, Departamento de Fármacos e Medicamentos, Universidade Estadual Paulista, Rodovia Araraquara-Jau Km 1 CP 502, Araraquara, SP, 14801-902, Brazil

    Adelia Emilia de Almeida, Ana Luiza Ribeiro Souza & Maria Palmira Daflon Gremião

  2. Departamento de Química Analítica, Universidade Estadual Paulista, Instituto de Química, R. Prof. Francisco Degni, s/n, CP 355, Araraquara, SP, 14801-970, Brazil

    Douglas Lopes Cassimiro, Clóvis Augusto Ribeiro & Marisa Spirandeli Crespi

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  1. Adelia Emilia de Almeida
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  2. Ana Luiza Ribeiro Souza
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  3. Douglas Lopes Cassimiro
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  4. Maria Palmira Daflon Gremião
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  5. Clóvis Augusto Ribeiro
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  6. Marisa Spirandeli Crespi
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Correspondence to Adelia Emilia de Almeida.

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de Almeida, A.E., Souza, A.L.R., Cassimiro, D.L. et al. Thermal characterization of solid lipid nanoparticles containing praziquantel. J Therm Anal Calorim 108, 333–339 (2012). https://doi.org/10.1007/s10973-011-1814-0

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  • DOI: https://doi.org/10.1007/s10973-011-1814-0

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