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Thermal behaviour studies of procaine and benzocaine

Part 1. Kinetic analysis of the active substances under non-isothermal conditions

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Abstract

The analysed substances, procaine and benzocaine, are two anaesthetic agents currently being administered in tablet form, also in the topical (cream, gel, balm) and injectable dosage forms. The TG/DTG/DTA curves were obtained in air at different heating rates. For determination of the heat effects, the DTA curves (in μV) were changed with the heat flow curves (in mW), so that the peak area corresponds to an energy in J g−1 or kJ mol−1. The non-isothermal experiments are preformed to investigate the thermal degradation process of these active substances, both as a solid and are performed in a dynamic atmosphere of air at different heating rates, by heating from room temperature to 500 °C. The kinetic analysis was performed using the TG data in air for the first step of substance’s decomposition at four heating rates: 7, 10, 12 and 15 °C min−1. The data were processed according to an appropriate strategy to the following kinetic methods: Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa, Friedman and NPK, to obtain realistic kinetic parameters, even if the decomposition process is a complex one. Thermal analysis was supplemented using Fourier Transform infrared spectroscopy coupled with the TG device to identify the anaesthetics with any products which may have formed (EGA—the evolved gas analysis).

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Authors and Affiliations

  1. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timişoara, Romania

    Adriana Fulias & Ionuţ Ledeţi

  2. Research Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timişoara, Romania

    Gabriela Vlase, Carmen Grigorie, Mihai Bilanin & Titus Vlase

  3. Pharmacy and Dentistry, Department of Pharmacy, Faculty of General Medicine, “Vasile Goldis” West University of Arad, 31 H. Coandă St., 310429, Arad, Romania

    Paul Albu

Authors
  1. Adriana Fulias
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  2. Gabriela Vlase
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  3. Carmen Grigorie
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  4. Ionuţ Ledeţi
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  5. Paul Albu
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  6. Mihai Bilanin
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  7. Titus Vlase
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Correspondence to Gabriela Vlase.

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Fulias, A., Vlase, G., Grigorie, C. et al. Thermal behaviour studies of procaine and benzocaine. J Therm Anal Calorim 113, 265–271 (2013). https://doi.org/10.1007/s10973-013-2959-9

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  • DOI: https://doi.org/10.1007/s10973-013-2959-9

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