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Bioactive Peptides from Marine Ascidians and Future Drug Development–A Review

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International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Abstract

Marine ascidians are considered as one of the richest sources of bioactive compounds. The extraction and utilization of marine peptides have been attracted much attention owing to their potential health benefits. Most of the bioactive compounds from marine ascidians are already in different phases of the clinical and preclinical pipeline. They can be used in different functional and nutraceutical values due to their antineoplastic, antihypertensive, antioxidant, and antimicrobial properties. The screening in vivo and in vitro bioassays are coupled to the purification process for the exploration of its biological interest which is of great value. The growing significance to study marine natural products results from the discovery of novel pharmacological tools including potent anticancer drugs and other drugs are in clinical/pre-clinical trials. The present review highlights the recent research progress in marine ascidians’ peptides and its prospects for the future pharmaceutical development.

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Acknowledgements

This study was funded by Department of Science and Technology-Science and Engineering Research board (DST-SERB), India (SB/YS/LS-374/2013).

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Authors and Affiliations

  1. Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India

    Velusamy Arumugam & Umamaheswari Sundaresan

  2. Department of Medical Biotechnology, Chettinad Academy of Research and Education, Kelambakkam, Chennai, Tamil Nadu, 603013, India

    Manigandan Venkatesan & Saravanan Ramachandran

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  1. Velusamy Arumugam
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  2. Manigandan Venkatesan
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  3. Saravanan Ramachandran
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  4. Umamaheswari Sundaresan
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Correspondence to Umamaheswari Sundaresan.

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Arumugam, V., Venkatesan, M., Ramachandran, S. et al. Bioactive Peptides from Marine Ascidians and Future Drug Development–A Review. Int J Pept Res Ther 24, 13–18 (2018). https://doi.org/10.1007/s10989-017-9662-9

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