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Three-component one-pot synthesis of 4,6-diarylpyrimidin- 2(1H)-ones under solvent-free conditions in the presence of sulfamic acid as a green and reusable catalyst

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Abstract

A rapid and efficient one-pot method for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones and related heterocycles is described. The condensation of acetophenone derivatives, aldehydes and urea in the presence of sulfamic acid was employed to synthesize a variety of pyrimidinones in moderate to excellent yields. The scope and limitations of this method are described.

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Authors and Affiliations

  1. Department of Chemistry, School of Sciences, Azzahra University, Vanak, Tehran, Iran

    Majid M. Heravi, Leila Ranjbar, Fatemeh Derikvand & Behnoush Alimadadi

Authors
  1. Majid M. Heravi
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  2. Leila Ranjbar
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  3. Fatemeh Derikvand
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  4. Behnoush Alimadadi
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Correspondence to Majid M. Heravi or Fatemeh Derikvand.

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Heravi, M.M., Ranjbar, L., Derikvand, F. et al. Three-component one-pot synthesis of 4,6-diarylpyrimidin- 2(1H)-ones under solvent-free conditions in the presence of sulfamic acid as a green and reusable catalyst. Mol Divers 12, 191–196 (2008). https://doi.org/10.1007/s11030-008-9089-5

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  • DOI: https://doi.org/10.1007/s11030-008-9089-5

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