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Microwave-assisted one-pot multi-component reaction: synthesis of novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives

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Abstract

One-pot multi-component reaction of 3-cyanoacetyl indole, aromatic aldehydes and ethyl acetoacetate in the presence of \(\hbox {InCl}_{3}/\hbox {NH}_{4}\)OAc under microwave irradiation for 2–7 min afforded novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives, respectively, in good yield.

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Fig. 1
Scheme 1
Scheme 2

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Abbreviations

s:

Singlet

d:

Doublet

t:

Triplet

q:

Quartet

J:

Coupling constant

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Acknowledgments

The authors thank DST, New Delhi for financial support. SM thanks CSIR, New Delhi for Senior Research Fellowship.

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Authors and Affiliations

  1. Medicinal Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat,  785006, Assam, India

    Pallabi Borah, P. Seetham Naidu, Swarup Majumder & Pulak J. Bhuyan

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  1. Pallabi Borah
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  2. P. Seetham Naidu
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  3. Swarup Majumder
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  4. Pulak J. Bhuyan
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Correspondence to Pulak J. Bhuyan.

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Borah, P., Naidu, P.S., Majumder, S. et al. Microwave-assisted one-pot multi-component reaction: synthesis of novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives. Mol Divers 18, 759–767 (2014). https://doi.org/10.1007/s11030-014-9533-7

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