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Molecular diversity of spirooxindoles. Synthesis and biological activity

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Abstract

Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.

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Authors and Affiliations

  1. State Scientific Institution, “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Lenina Pr., 60, Kharkov, 61002, Ukraine

    Tetyana L. Pavlovska & Victoria V. Lipson

  2. National University of Pharmacy, Pushkinska Str., 53, Kharkov, 61002, Ukraine

    Ruslan Gr. Redkin

  3. State Institution “V.Ya. Danilevsky Institute of Endocrine Pathology Problems”, Academy of Medical Sciences of Ukraine, Artema Str., 10, Kharkov, 61002, Ukraine

    Victoria V. Lipson

  4. Dmytro Atamanyuk Mutabilis, 102 Av. Gaston Roussel, Romainville, 93230, France

    Dmytro V. Atamanuk

Authors
  1. Tetyana L. Pavlovska
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  2. Ruslan Gr. Redkin
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  3. Victoria V. Lipson
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  4. Dmytro V. Atamanuk
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Corresponding author

Correspondence to Tetyana L. Pavlovska.

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Pavlovska, T.L., Redkin, R.G., Lipson, V.V. et al. Molecular diversity of spirooxindoles. Synthesis and biological activity. Mol Divers 20, 299–344 (2016). https://doi.org/10.1007/s11030-015-9629-8

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  • DOI: https://doi.org/10.1007/s11030-015-9629-8

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