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One-pot tandem Ugi-4CR/\(\hbox {S}_{N}\)Ar approach to highly functionalized quino[2,3-b][1,5]benzoxazepines

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Abstract

We have developed a convenient and facile method for the synthesis of functionalized diverse quino[2,3-b][1,5]benzoxazepines. These new compounds were synthesized through a one-pot sequential Ugi-4CR/base-free intramolecular aromatic nucleophilic substitution \((\hbox {S}_{N}\hbox {Ar})\) reaction in moderate to good yields from readily available starting materials. Structural confirmation of the products is confirmed by analytical data and X-ray crystallography.

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Acknowledgments

The authors thank the University of Tehran for the financial support of this research.

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Authors and Affiliations

  1. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155 6455, Tehran, Iran

    Mehdi Ghandi, Nahid Zarezadeh & Alireza Abbasi

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  1. Mehdi Ghandi
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Correspondence to Mehdi Ghandi.

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Ghandi, M., Zarezadeh, N. & Abbasi, A. One-pot tandem Ugi-4CR/\(\hbox {S}_{N}\)Ar approach to highly functionalized quino[2,3-b][1,5]benzoxazepines. Mol Divers 20, 483–495 (2016). https://doi.org/10.1007/s11030-015-9651-x

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