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Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds

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Abstract

In an attempt to search for new natural products-based antifungal agents, a series of novel dehydroabietic acid derivatives bearing a 1,3,4-thiadiazole-thiazolidinone moiety were designed and synthesized. The primary bioassay used showed that at a concentration of \(50\,\upmu \hbox {g}/\hbox {mL}\), the target compounds 3c, 3f, and 3n exhibited excellent antifungal activity (91.3 % inhibition) against Gibberella zeae, which was equivalent to the commercial antifungal drug azoxystrobin (positive control).

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Acknowledgments

This study was financially supported by the National Natural Science Foundation of China (No. 31060100) and the Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization (No.FPRU2016-1). The authors are thankful to the Research Institute of Elemento-organic Chemistry, Nankai University, China, for the bioassay test.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, People’s Republic of China

    Naiyuan Chen, Wengui Duan, Guishan Lin, Luzhi Liu & Rui Zhang

  2. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, 541006, Guangxi, People’s Republic of China

    Dianpeng Li

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  1. Naiyuan Chen
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  2. Wengui Duan
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  3. Guishan Lin
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  4. Luzhi Liu
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Correspondence to Wengui Duan.

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Chen, N., Duan, W., Lin, G. et al. Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds. Mol Divers 20, 897–905 (2016). https://doi.org/10.1007/s11030-016-9691-x

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  • DOI: https://doi.org/10.1007/s11030-016-9691-x

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