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XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case–control studies

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Abstract

The published data on the association between xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism and esophageal cancer (EC) remained controversial. The present meta-analysis of literatures was performed to derive a more precise estimation of the relationship. A comprehensive literature search was conducted to identify all case–control studies of Lys751Gln polymorphism and risk for two main types of EC: esophageal adenocarcinoma (EADC) and esophageal squamous cell carcinoma (ESCC). A total of 12 studies were identified to the meta-analysis, including 2,575 cases (1,294 ESCC and 1,281 EADC) and 4,951 controls (1,891 ESCC and 3,060 EADC). Random-effects or fix-effects model was used according to between-study heterogeneity. The odds ratio (OR) for the variant homozygous genotype Gln/Gln of the Lys751Gln polymorphism, compared with the wild type homozygote Lys/Lys, was 1.26, with 95% confidence interval (95% CI) 1.02–1.56, for EADC risk without between-study heterogeneity. When stratified by ethnicity, statistically significantly elevated risk was found among Chinese (Gln/Gln vs. Lys/Lys: OR 2.45, 95% CI = 1.10–5.44). However, no significant associations were found between XPD Lys751Gln polymorphism and EC risk when all studies pooled into the meta-analysis (Lys/Gln vs. Lys/Lys: OR 1.07, 95% CI = 0.88–1.28; Gln/Gln vs.us Lys/Lys: OR 1.25, 95% CI = 0.92–1.71; dominant model: OR 1.09, 95% CI = 0.90–1.33). In conclusion, this meta-analysis suggests that the Lys751Gln genetic polymorphism may be a potential biomarker of EC susceptibility in Chinese populations. And a study with the larger sample size is needed to further evaluate gene–environment interaction on XPD Lys751Gln polymorphism and EC risk.

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Authors and Affiliations

  1. Institute of Genetic Engineering, Southern Medical University, Guangzhou, China

    Da-Peng Ding & Wen-Li Ma

  2. Central Laboratory, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi, China

    Xiao-Feng He

  3. College of Pharmacy, Jinan University, Guangzhou, China

    Ying Zhang

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  1. Da-Peng Ding
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  2. Wen-Li Ma
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  3. Xiao-Feng He
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Correspondence to Wen-Li Ma or Ying Zhang.

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Ding, DP., Ma, WL., He, XF. et al. XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case–control studies. Mol Biol Rep 39, 2533–2540 (2012). https://doi.org/10.1007/s11033-011-1005-x

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