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The Interplay Between NSAIDs and Candida albicans on the Gastrointestinal Tract of Guinea Pigs

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An Erratum to this article was published on 04 May 2013

Abstract

Recent studies suggest that Candida albicans colonization is associated with several gastrointestinal inflammatory disorders and is also responsible for the delay in ulcer healing. No data are reported about the effects of C. albicans on the nonsteroidal anti-inflammatory drugs (NSAIDs)-induced necroinflammatory lesions. On the other hand, beneficial effects of NSAIDs regarding the colonization potential with C. albicans have been reported. Our aim was to investigate whether the association between NSAIDs and C. albicans could potentially induce necroinflammatory lesions in the guinea pigs gastric and enteral mucosa. Three interventional groups of 11 guinea pigs each were investigated after 5 days of receiving indomethacin, C. albicans or the association of both. C. albicans and necroinflammatory lesions were graded based on histological examinations. Statistical analysis used Mann–Whitney nonparametric test. NSAIDs did not significantly decrease C. albicans colonization grades on gastrointestinal mucosa. Administration of indomethacin subsequent to C. albicans determined significantly more severe necroinflammatory lesions compared to group that only received C. albicans. The association of NSAIDs and C. albicans did not cause significantly more severe degenerative or inflammatory lesions compared to the administration of only NSAIDs in this experimental model. Associations between NSAIDs and C. albicans caused significantly more severe necroinflammatory injuries than the lesions produced by C. albicans, without enhancing the mucosal injury or inflammation caused by NSAIDs.

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Acknowledgments

This paper was supported by POSDRU/89/1.5/S/62371 project.

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Authors and Affiliations

  1. Microbiology Department, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, 3-5 Calea Mãnãştur Street, 400372, Cluj-Napoca, Romania

    George C. Nadăş, Nicodim I. Fiţ, Chirilă Flore & Sorin Răpuntean

  2. Pathology Department, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, 3-5 Calea Mãnãştur Street, 400372, Cluj-Napoca, Romania

    Marian A. Taulescu, Cosmina M. Bouari & Cornel Catoi

  3. 3rd Medical Clinic, Regional Institute of Gastroenterology and Hepatology, University of Medicine and Pharmacy, 19-21 Croitorilor Street, 400162, Cluj-Napoca, Romania

    Lidia Ciobanu

Authors
  1. George C. Nadăş
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  2. Marian A. Taulescu
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  3. Lidia Ciobanu
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  4. Nicodim I. Fiţ
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  5. Chirilă Flore
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  6. Sorin Răpuntean
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  7. Cosmina M. Bouari
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  8. Cornel Catoi
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Corresponding author

Correspondence to Marian A. Taulescu.

Additional information

George C. Nadăş and Lidia Ciobanu contributed equally to this work.

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Nadăş, G.C., Taulescu, M.A., Ciobanu, L. et al. The Interplay Between NSAIDs and Candida albicans on the Gastrointestinal Tract of Guinea Pigs. Mycopathologia 175, 221–230 (2013). https://doi.org/10.1007/s11046-013-9613-8

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  • DOI: https://doi.org/10.1007/s11046-013-9613-8

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