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The Relationship Between Protein S-Nitrosylation and Human Diseases: A Review

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Abstract

S-nitrosylation (SNO) is a covalent post-translational oxidative modification. The reaction is the nitroso group (–NO) to a reactive cysteine thiol within a protein to form the SNO. In recent years, a variety of proteins in human body have been found to undergo thiol nitrosylation under specific conditions. Protein SNO, which is closely related to cardiovascular disease, Parkinson’s syndrome, Alzheimer’s disease and tumors, plays an important role in regulatory mechanism of protein function in both physiological and pathological pathways, such as in cellular homeostasis and metabolism. This review discusses possible molecular mechanisms protein SNO modification, such as the role of NO in vivo and the formation mechanism of SNO, with particular emphasis on mechanisms utilized by SNO to cause certain diseases of human. Importantly, the effect of SNO on diseases is multifaceted and multi-channel, and its critical value in vivo is not well defined. Intracellular redox environment is also a key factor affecting its level. Therefore, we should pay more attention to the equilibrium relationship between SNO and denitrosylation pathway in the future researches. These findings provide theoretical support for the improvement or treatment of diseases from the point of view of SNO.

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Acknowledgements

The authors gratefully acknowledge the financial support of National Natural Science Foundation of China (31701531), Hebei Natural Science Foundation (C2018201146), and One Province One School Project of China.

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  1. Key Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, No. 180 Wusidong Road, Baoding, 071002, People’s Republic of China

    Yadi Zhang, Yuzhen Deng, Xiaoxi Yang, Hongmei Xue & Yumiao Lang

  2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, People’s Republic of China

    Yadi Zhang, Yuzhen Deng, Xiaoxi Yang, Hongmei Xue & Yumiao Lang

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  1. Yadi Zhang
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Writing—original draft preparation, YZ and YD; writing—review and editing, YL, HX and XY; supervision, YL. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Yumiao Lang.

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Zhang, Y., Deng, Y., Yang, X. et al. The Relationship Between Protein S-Nitrosylation and Human Diseases: A Review. Neurochem Res 45, 2815–2827 (2020). https://doi.org/10.1007/s11064-020-03136-6

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  • DOI: https://doi.org/10.1007/s11064-020-03136-6

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