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Solubility of Diclofenac Acid Form from Solid Dispersions

  • Drug Synthesis Methods and Manufacturing Technology
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Pharmaceutical Chemistry Journal Aims and scope

The influence of solid dispersions (SD) on diclofenac solubility was determined by studying diclofenac (acid form) and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP). SD formation increased the solubility and dissolution rate of the non-steroidal anti-inflammatory drug (NSAID). Diclofenac solubility from the SD with PVP increased by 2.5 times; from the SD with PEG (solvent evaporation method), by 8 times compared with diclofenac drug substance. A combination of physicochemical methods showed that the improved release of diclofenac from the SD occurred because of reduced crystallinity, formation of drug solid solutions in the polymer matrix, and formation of a colloidal drug solution.

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Acknowledgments

The work was supported by the Ministry of Education under the auspices of the state contract for 2014.

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    I. I. Krasnyuk Jr., L. V. Ovsyannikova, O. I. Nikulina, A. V. Belyatskaya, I. I. Krasnyuk, Yu. Ya. Kharitonov, V. V. Grikh & L. A. Korol’

  2. Research and Education Center of Collective Use, People’s Friendship University of Russia, Moscow, 117918, Russia

    Yu. A. Obidchenko & A. N. Vorob’ev

Authors
  1. I. I. Krasnyuk Jr.
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  2. L. V. Ovsyannikova
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  3. O. I. Nikulina
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  4. A. V. Belyatskaya
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  5. I. I. Krasnyuk
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  6. Yu. Ya. Kharitonov
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  7. V. V. Grikh
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  8. L. A. Korol’
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  9. Yu. A. Obidchenko
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  10. A. N. Vorob’ev
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 11, pp. 23 – 27, November, 2014.

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Krasnyuk, I.I., Ovsyannikova, L.V., Nikulina, O.I. et al. Solubility of Diclofenac Acid Form from Solid Dispersions. Pharm Chem J 48, 733–737 (2015). https://doi.org/10.1007/s11094-015-1183-2

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  • DOI: https://doi.org/10.1007/s11094-015-1183-2

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