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Synthesis, Antimicrobial Properties, and Toxicity of a Nanobiocomposite Based on Ag(0) Particles and Poly(1-Vinyl-1,2,4-Triazole)

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The synthesis of a water-soluble polymer nanocomposite with Ag(0) particles encapsulated in a poly(1-vinyl-1,2,4-triazole) matrix is reported. The nanocomposite contains isolated spherical Ag(0) particles sized from 2 to 8 nm that are uniformly distributed in the polymer matrix and have a characteristic plasmonic absorption maximum at 412 nm. The new nanocomposite belongs to marginally hazardous category 4. The structural morphology of animal brain tissue is not disturbed after subacute intragastric injection. The bacteriostatic concentration of the nanocomposite varies in the range 0.5 – 32 μg/mL; bactericidal, 1 – 64 μg/mL.

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Authors and Affiliations

  1. East-Siberian Medico-Ecological Research Institute, 3 12a Mikroraion, Angarsk, Irkutsk Oblast, 665827, Russia

    L. M. Sosedova, M. A. Novikov & E. A. Titov

  2. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorskogo St, Irkutsk, 664033, Russia

    A. S. Pozdnyakov, S. A. Korzhova, T. G. Ermakova & G. F. Prozorova

Authors
  1. L. M. Sosedova
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  2. M. A. Novikov
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  3. E. A. Titov
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  4. A. S. Pozdnyakov
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  5. S. A. Korzhova
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  6. T. G. Ermakova
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  7. G. F. Prozorova
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Corresponding author

Correspondence to L. M. Sosedova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 11, pp. 37 – 41, November, 2018.

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Sosedova, L.M., Novikov, M.A., Titov, E.A. et al. Synthesis, Antimicrobial Properties, and Toxicity of a Nanobiocomposite Based on Ag(0) Particles and Poly(1-Vinyl-1,2,4-Triazole). Pharm Chem J 52, 912–916 (2019). https://doi.org/10.1007/s11094-019-01925-0

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  • DOI: https://doi.org/10.1007/s11094-019-01925-0

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