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Synthesis and Antimicrobial Activity of 3-Phenyl-1-Methylquinolin-2-One Derivatives

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A series of quaternary salts were obtained by reacting 3-(4-bromoacetylphenyl)-1-methylquinolin-2(1H)-one with Py, 4-methylpyridine, quinoline, benzo[f]quinoline, and triphenylphosphine. Derivatives of thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine were produced using dinucleophilic reagents. Several of the synthesized compounds possessed high antimicrobial activity, indicating that further research on this series of compounds was promising.

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Authors and Affiliations

  1. Yuriy Fedkovych Chernivtsi National University, 25 Lesi Ukrainki St., Chernivtsi, 58012, Ukraine

    O. V. Elenich, O. V. Skripskaya, O. S. Lyavinets & P. I. Yagodinets

  2. Ivan Franko National University of Lviv, 6 Kirilla i Mefodiya St., Lviv, 79005, Ukraine

    R. Z. Lytvyn, Kh. E. Pitkovych & M. D. Obushak

  3. L. I. Medved Research Center of Preventive Toxicology, Food and Chemical Safety, Department of Medical and Environmental Problems, Ministry of Health, Ukraine, 30 Fedkovych St., Chernivtsi, 58022, Ukraine

    O. V. Blinder

Authors
  1. O. V. Elenich
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  2. R. Z. Lytvyn
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  3. O. V. Blinder
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  4. O. V. Skripskaya
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  5. O. S. Lyavinets
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  6. Kh. E. Pitkovych
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  7. M. D. Obushak
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  8. P. I. Yagodinets
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Corresponding author

Correspondence to M. D. Obushak.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 12, pp. 7 – 11, December, 2018.

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Elenich, O.V., Lytvyn, R.Z., Blinder, O.V. et al. Synthesis and Antimicrobial Activity of 3-Phenyl-1-Methylquinolin-2-One Derivatives. Pharm Chem J 52, 969–974 (2019). https://doi.org/10.1007/s11094-019-01935-y

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  • DOI: https://doi.org/10.1007/s11094-019-01935-y

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