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Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions

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Pharmaceutical Chemistry Journal Aims and scope

The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, 119991, Russia

    A. V. Belyatskaya, I. I. Krasnyuk Jr, I. I. Krasnyuk, O. I. Stepanova, T. M. Kosheleva, T. P. Kudinova & M. M. Maryanyan

  2. People’s Friendship University of Russia (RUDN University), Moscow, 117198, Russia

    A. N. Vorob’ev

Authors
  1. A. V. Belyatskaya
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  2. I. I. Krasnyuk Jr
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  3. I. I. Krasnyuk
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  4. O. I. Stepanova
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  5. T. M. Kosheleva
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  6. T. P. Kudinova
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  7. A. N. Vorob’ev
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  8. M. M. Maryanyan
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Correspondence to A. V. Belyatskaya.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 12, pp. 39 – 44, December, 2018.

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Belyatskaya, A.V., Krasnyuk, I.I., Krasnyuk, I.I. et al. Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions. Pharm Chem J 52, 1001–1006 (2019). https://doi.org/10.1007/s11094-019-01941-0

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  • DOI: https://doi.org/10.1007/s11094-019-01941-0

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