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Assessment of the Acute Toxicity and Analgesic Activity of Ethyl-6-Amino-4-Aryl-5-Cyano-2,4-Dihydropyrano-2,3-C]-Pyrazole-3-Carboxylates

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Pharmaceutical Chemistry Journal Aims and scope

The acute toxicity and analgesic activity of compounds of the ethyl-6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate series were investigated. Study compounds were found to be essentially nontoxic and to have analgesic activity.

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References

  1. V. L. Gein, T. M. Zamaraeva, N. A. Buzmakova, et al., Khim.-Farm. Zh., 49(8), 18 – 20 (2015); Pharm. Chem. J., 49(8), 512 – 514 (2015).

  2. E. N. El-Tamany, F. A. El-Shahed, and B. H. Mohamed, J. Serb. Chem. Soc., 64, 9 (1999).

    CAS  Google Scholar 

  3. A. Feurer, J. Luithle, S. Wirtz, G. Koenig, et al., (Bayer Healthcare AG, Germany), WO 2004009589; Chem. Abstr., 140, 146157 (2004).

  4. A. M. Shestopalov, A. A. Shestopalov, and L. A. Rodinovskaya, Synthesis, 1, 1 – 25 (2008).

    Article  CAS  Google Scholar 

  5. L. A. Rodinovskaya, A. M. Shestopalov, A. Gromova, et al., Synthesis, 14, 2357 – 2370 (2006).

  6. Suman Pal, et al., Tetrahedron Let., 54, 5434 – 5440 (2013).

    Article  CAS  Google Scholar 

  7. J. L. Wang, D. Liu, Z. J. Zhang, S. Shan, et al., Proc. Natl. Acad. Sci. U. S. A., 97, 7124 (2000).

  8. M. R. Nadia, Y. K. Nahed, A. Fahmyb, and A. A. F. Ei-Sayeda, Pharm. Chem. J., 2, 400 (2010).

    Google Scholar 

  9. V. L. Gein, T. M. Zamaraeva, and P. A. Slepukhin, Tetrahedron Let., 55, 4525 – 4528 (2014).

    Article  CAS  Google Scholar 

  10. Guidelines for Preclinical Studies of Medicines [in Russian], A. N. Mironov (ed.), Grif i K, Moscow (2012).

  11. V. V. Prozorovskii, M. P. Prozorovskaya, and V. M. Demchenko, Farmakol. Toksikol., 41(4), 497 – 502 (1978).

    CAS  Google Scholar 

  12. Guidelines for Experimental (Preclinical) Studies of Novel Pharmacological Substances [in Russian], Meditsina, Moscow (2005).

  13. V. L. Gein, O. V. Bobrovskaya, G. V. Seliverstov, et al., Khim.-Farm. Zh., 51(3), 25 – 28 (2017); Pharm. Chem. J., 51(3), 187 – 190 (2017).

  14. K. K. Sidorov, Farmakol. November. Promyshl. Khim. Veshch., 13, 47 – 51 (1973).

    Google Scholar 

  15. A. V. Piskarev, V. S. Nesterenko, and S. I. Suminov, Farmakol. Toksikol., No. 1, 48 – 54 (1973).

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 2 Polevaya Street, 614990, Perm, Russia

    O. N. Gein, T. M. Zamaraeva & V. L. Gein

Authors
  1. O. N. Gein
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  2. T. M. Zamaraeva
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  3. V. L. Gein
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Correspondence to V. L. Gein.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 1, pp. 41 – 43, January, 2019.

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Gein, O.N., Zamaraeva, T.M. & Gein, V.L. Assessment of the Acute Toxicity and Analgesic Activity of Ethyl-6-Amino-4-Aryl-5-Cyano-2,4-Dihydropyrano-2,3-C]-Pyrazole-3-Carboxylates. Pharm Chem J 53, 40–42 (2019). https://doi.org/10.1007/s11094-019-01952-x

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  • DOI: https://doi.org/10.1007/s11094-019-01952-x

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