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Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives

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Pharmaceutical Chemistry Journal Aims and scope

Four new 1,3,4-bis-oxadiazole derivatives were synthesized, two of them bearing quaternary ammonium salts. The newly synthesized bis-1,3,4-oxadiazoles were investigated for their antibacterial activity against various Gram-positive and Gram-negative strains of bacteria. The target products were prepared from 2-(dimethylamino)ethyl methacrylate (DMAEMA) or 2-(diethylamino)ethyl methacrylate (DEAEMA) via reactions with hexanedioic acid. The structures of all synthesized compounds were confirmed by IR, 1H-NMR, and 13C-NMR spectroscopy. The results of biological activity testing showed that two compounds exhibited the best antibacterial activity against Citrobacterfreundii (ATCC 8090) and Methicillin-resistant Staphylococcus aureus (ATCC 43300) strains.

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Acknowledgements

Prof. Dr. Taoufik Rohand thanks the University Cadi Ayyad and specially the Faculty Polidisciplinaire of Safi for the profesorship and the Laboratory of Analytical and Molecular Chemistry for financial support.

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Authors and Affiliations

  1. Laboratoire de Chimie Analytique et Moléculaire, Département de Chimie, Université Cadi Ayyad, Faculté Polydisciplinaire Safi, Safi, Morocco

    Taoufik Rohand

  2. Laboratoire de ChimieThérapeutique, Université Mohamed V, Faculté de Médecineet de Pharmacie de Rabat, Av Med Belarbi Elalaoui, BP 6203, Rabat-Institus, Rabat, Morocco

    Youssef Ramli

  3. Department of Chemistry, The Assam Kaziranga University, Karaikhowa, Jorhat, Assam, 785006, India

    Mukulesh Baruah

  4. Department of Organic Chemistry, University of Chemistry and Technology, Prague, Czech Republic

    Jan Budka

  5. Natural Products Chemistry Division, CSIR, North East Institute of Science and Technology, Jorhat, Assam, 785006, India

    Archana M. Das

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  1. Taoufik Rohand
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  2. Youssef Ramli
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  3. Mukulesh Baruah
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  4. Jan Budka
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  5. Archana M. Das
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Correspondence to Taoufik Rohand.

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Rohand, T., Ramli, Y., Baruah, M. et al. Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives. Pharm Chem J 53, 150–154 (2019). https://doi.org/10.1007/s11094-019-01969-2

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  • DOI: https://doi.org/10.1007/s11094-019-01969-2

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