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Synthesis, Antimicrobial Activity, and Behavioral Response Effects of N-Substituted 4-Aryl-2-Hydroxy-4-Oxobut-2-Enoic Acid Hydrazides and Their Metal Complexes

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Pharmaceutical Chemistry Journal Aims and scope

N-Substituted 4-aryl-2-hydroxy-4-oxobut-2-enoic acid hydrazides and their complexes with Ni(II), Mn(II), Co(II), Cu(II), and Zn(II) were prepared. Their antimicrobial activity and behavioral response effects in mice were studied. Compounds with low acute toxicities and activities comparable to or exceeding those of the reference drugs were discovered.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, Perm, Perm Krai, 614990, Russia

    N. A. Pulina, A. S. Kuznetsov, A. I. Krasnova & V. V. Novikova

Authors
  1. N. A. Pulina
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  2. A. S. Kuznetsov
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  3. A. I. Krasnova
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  4. V. V. Novikova
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Corresponding author

Correspondence to N. A. Pulina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 3, pp. 30 – 34, March, 2019.

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Pulina, N.A., Kuznetsov, A.S., Krasnova, A.I. et al. Synthesis, Antimicrobial Activity, and Behavioral Response Effects of N-Substituted 4-Aryl-2-Hydroxy-4-Oxobut-2-Enoic Acid Hydrazides and Their Metal Complexes. Pharm Chem J 53, 220–224 (2019). https://doi.org/10.1007/s11094-019-01983-4

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  • DOI: https://doi.org/10.1007/s11094-019-01983-4

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