A synthetic method for a series of new coumarin conjugates was developed. Their structures and physicochemical properties were determined by modern spectral methods (IR, NMR, ESI-MS). The anticoagulant activity was studied in vivo by determining the prothrombin time (PT). Compounds 4a (PT = 10.88 ± 0.56 sec) and 4b (13.10 ± 3.56 sec) were the most active and comparable to the reference drug warfarin (7.97 ± 1.93 sec).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 5, pp. 8 – 12, May, 2019.
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Bang, N.C., Abyshev, A.Z. & Ivkin, D.Y. Synthesis and In Vivo Evaluation of New Coumarin Conjugates as Potential Indirect-Action Anticoagulants. Pharm Chem J 53, 419–422 (2019). https://doi.org/10.1007/s11094-019-02013-z
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DOI: https://doi.org/10.1007/s11094-019-02013-z