Skip to main content
SpringerLink
Log in

Modern Preservatives of Microbiological Stability (Review)

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Modern antimicrobial preservatives authorized for use in dosage form technology are reviewed. The nomenclature and various classifications of preservatives according to chemical nature, mechanism and spectrum of antimicrobial action, optimum effective concentrations for antimicrobial activity, and separate factors affecting the activity of antimicrobial preservatives in various dosage forms, e.g., optimum solution pH values and specific adsorbents reducing preservative activity, are presented. Antimicrobial preservatives used widely in pharmaceutical technology, i.e., parabens, sorbic acid and its salts, benzoic acid and its salts, and benzalkonium chloride, are discussed in detail. Ascience-based approach to selecting antimicrobial preservatives is shown to produce the most stable and safest medicines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. N. N. Firsov, Microbiology: Dictionary of Terms [in Russian], Drofa, Moscow, 2006.

    Google Scholar 

  2. S. P. Anand and N. Sati, Int. J. Pharm. Sci. Res., 4(7), 2496 – 2501 (2013).

    Google Scholar 

  3. O. E. Belikov and T. V. Puchkova, Preservatives in Cosmetics and Sanitary Media [in Russian], Shkola Kosmeticheskikh Khimikov, Moscow, 2003.

    Google Scholar 

  4. State Pharmacopoeia of the Russian Federation [in Russian], XIIIth Ed., Moscow, 2015; Federal Electronic Medical Library; http: // femb.ru / feml (accessed July 25, 2017).

  5. European Pharmacopoeia, 8.0 Ed., 2014.

  6. Pharmacopeia of the United States, USP38 / NF33, 2015.

  7. H. A. Pawar, et al., Int. J. Pharm. Phytopharmacol. Res., 1(2), 78 – 88 (2011).

    CAS  Google Scholar 

  8. S. V. W. Sutton and D. Porter, PDA J. Pharm. Sci. Technol., 56(6), 300 – 311 (2002).

    PubMed  Google Scholar 

  9. A. V. Titova, Doctoral Dissertation, Moscow, 2006.

  10. E. Lyuk and M. Yager, Preservatives in the Food Industry. Properties and Applications [in Russian], GIORD, St. Petersburg, 2000.

    Google Scholar 

  11. L. V. Kolosova, Candidate Dissertation, St. Petersburg, 2016.

  12. A. Singh, P. K. Sharma, and G. Garg, Int. J. Pharm. Bio Sci., 1(4), 601 – 612 (2010).

    Google Scholar 

  13. J.-S. Choi, Y.-R. Lee, Y.-M. Ha, et al., J. Food Sci., 79(6), M1159 – M1167 (2014).

    Article  CAS  Google Scholar 

  14. Analytical Portal of the Chemical Industry “New Chemical Technologies” [in Russian]; http: // www.newchemistry.ru/letter. php?nid=1629 (accessed July 2, 2017).

  15. S. M. Shaikh, R. C. Doijad, A. S. Shete, et al., PharmaTutor, 4(5), 25 – 34 (2016).

    CAS  Google Scholar 

  16. L. V. Allen, Jr., Secundem Artem, 18(1), 1 – 8 (2014).

    Google Scholar 

  17. “EC changes allowed concentrations of another three preservatives, raw material and packaging for perfumes, cosmetics, and household chemicals,” Syr’e Upakovka dlya Parfyumerii, Kosmetiki i Bytovoi Khimii, No. 08 (159), October, 2014; https: // cosmetic-industry.com / es-menyaet-dopustimye-koncentracii-eshhe-trex-konservantov.html (accessed July 2, 2017).

  18. J. Swarbrick (ed.), Encyclopedia of Pharmaceutical Technology, PharmaceuTech, Informa Healthcare USA, Inc., USA, 2007.

    Google Scholar 

  19. C. A. Rasmussen, P. L. Kaufman, and J. A. Kiland, J. Ocul. Pharmacol. Ther., 30(2 – 3), 163 – 169 (2014).

    Article  CAS  Google Scholar 

  20. R. W. Yee, Curr. Opin. Ophthalmol., 18, 134 – 139 (2007).

    Article  Google Scholar 

  21. Iqbal Ahmad and K. A. Chishti, Pak. J. Pharm. Sci., 5(1), 25 – 36 (1992).

    CAS  PubMed  Google Scholar 

  22. D. P. Elder and P. J. Crowley, Am. Pharm. Rev. (2013); http: //www.americanpharmaceuticalreview.com/Featured-Articles / (accessed June 12, 2017).

  23. R. C. Rowe, P. J. Sheskey, and P. J. Weller (eds.), Handbook of Pharmaceutical Excipients, Fifth Ed., Pharmaceutical Press, 2006.

  24. S. C. Owen, Handbook of Pharmaceutical Excipients, Fifth Ed., Pharmaceutical Press, 2006.

  25. R. Johnson and R. Steer, Handbook of Pharmaceutical Excipients, Fifth Ed., Pharmaceutical Press, 2006.

  26. Preservative-Free Ophthalmic Products, Scope e-Knowledge Center Pvt Ltd., 2013; https: // www.slideshare.net/Scope-Knowledge/preservative-free-ophthalmic-products (accessed September 3, 2017).

  27. F. Brignole-Baudouin, L. Riancho, H. Liang, et al., J. Ocul. Pharmacol. Ther., 27, 273 – 280 (2011).

    Article  CAS  Google Scholar 

  28. C. Baudouin, A. Labbe, H. Liang, et al., Prog. Retinal Eye Res., 29, 312 – 334 (2010).

    Article  CAS  Google Scholar 

  29. P. D. Freeman and M. Y. Kahook, Expert Rev. Ophthalmol., 4, 59 – 64 (2009).

    Article  Google Scholar 

  30. S. P. Epstein, J. Ocul. Pharmacol. Ther., 25, 113 – 119 (2009).

    CAS  Google Scholar 

  31. M. Aihara, H. Oshima, and M. Araie, Acta Ophthalmol., 91, e7-e14 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, 119991, Russia

    M. N. Anurova, E. O. Bakhrushina, N. B. Demina & E. S. Panteleeva

Authors
  1. M. N. Anurova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. O. Bakhrushina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. B. Demina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. S. Panteleeva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. O. Bakhrushina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 6, pp. 54 – 61, June, 2019.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Anurova, M.N., Bakhrushina, E.O., Demina, N.B. et al. Modern Preservatives of Microbiological Stability (Review). Pharm Chem J 53, 564–571 (2019). https://doi.org/10.1007/s11094-019-02038-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-019-02038-4

Keywords

Search

Navigation