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Evaluation of the Antioxidant, Hepatoprotective, and Anti-Inflammatory Activities of Bisresorcinol Isolated from the Trunk of Heliciopsis Terminalis

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Pharmaceutical Chemistry Journal Aims and scope

A bisresorcinol, (8′Z)-3,5-dihydroxy-1-[16′-(3″,5″-dihydroxyphenyl)-8′-hexadecen-1′-yl]benzene (I), was isolated as an abundant constituent from the Vietnamese medicinal plant Heliciopsis terminalis (Kurz) Sleumer (Proteaceae). The antioxidant, hepatoprotective, and anti-inflammatory activities of compound I were tested in correlation with the use of H. terminalis as a hepatoprotective drug by ethnic people in Vietnam. Bisresorcinol I showed weak scavenging activity against DPPH radical at an EC50 value of 156.9 mg/mL. At a concentration of 100 mg/mL, compound I inhibited 19,78% of MDAproduction as one of the biomarkers for lipid peroxidation. Bisresorcinol I protected HepG2 cells against harmful CCl4. The hepatoprotective ability was observed at a concentration of 100 mg/mL with up to 44.42% cells alive, which was significantly higher than that in the control treated with CCl4 (29.93 %). The NO scavenging activity of I was determined in RAW 264.7 cells with an IC50 value of 71.15 mg/mL. Bisresorcinol I exhibited its anti-inflammatory activity through modulation of proinflammatory cytokines IL-6 and TNF-α as well as anti-inflammatory IL-10 in RAW264.7 cells.

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Acknowledgments

This research was funded by the National Program “Science and Technology for Sustainable Development of the Northwest Region” (Grant No. KHCN-TB. IIC/I3-I8). P.M.G. thanks Professor Hideaki Otsuka and Dr. Susumu Kawakami (Yasuda Women’s University, Hiroshima, Japan) for the measurements of HR-ESI-MS and 2D NMR spectra of compound I.

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Authors and Affiliations

  1. Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong Street, Hanoi, Vietnam

    Phan Minh Giang

  2. Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Nghia Do, Cau Giay, Hanoi, Vietnam

    Do Thi Thao & Nguyen Thi Nga

  3. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Vietnam

    Do Thi Thao

  4. National Institute for Drug Quality Control, Ministry of Health, 48 Hai Ba Trung Street, Hanoi, Vietnam

    Bui Van Trung

  5. Research Centre for Environmental Technology and Sustainable Development, VNU University of Science, Vietnam National University, Hanoi, 334 Nguyen Trai Street, Hanoi, Vietnam

    Duong Hong Anh & Pham Hung Viet

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  1. Phan Minh Giang
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  2. Do Thi Thao
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  3. Nguyen Thi Nga
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Correspondence to Phan Minh Giang.

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Giang, P.M., Thao, D.T., Nga, N.T. et al. Evaluation of the Antioxidant, Hepatoprotective, and Anti-Inflammatory Activities of Bisresorcinol Isolated from the Trunk of Heliciopsis Terminalis. Pharm Chem J 53, 628–634 (2019). https://doi.org/10.1007/s11094-019-02051-7

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  • DOI: https://doi.org/10.1007/s11094-019-02051-7

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