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Design, Synthesis, Drug-Likeness Studies and Bio-Evaluation of Some New Chalconeimines

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Pharmaceutical Chemistry Journal Aims and scope

Newly designed chalconeimines were synthesized, characterized and evaluated for their in vitro antioxidant and antibacterial effectiveness. Results of antioxidant activity assay reveal that all the tested compounds possess good to moderate antioxidant activity which is lower in comparison to that of a standard drug (gallic acid). On the other hand, all the synthesized compounds were found to exhibit a considerably wider spectrum of antibacterial activity, but it was also narrower in comparison to that of a standard drug (ciprofloxacin). Elucidation of structure—activity relationships revealed that electron donating groups (-OH, -OCH3) contribute more to antioxidant potency, whereas electron withdrawing groups (-Cl) impart better antibacterial effectiveness. Moreover, results of drug-likeness studies indicate that a reasonable correlation exists between the drug-like properties and antioxidant activity of the synthesized chalconeimines.

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Acknowledgements

The authors express their sincere thanks to Dr. K. Ravishankar, Principal, Sri Sai Aditya Institute of Pharmaceutical Sciences and Research, Surampalem, E. G. Dist., Andhra Pradesh (India) for his generous help and co-operation in studying out the antioxidant activity of synthesized compounds. The authors also wish to thank Mr. N. Sathish Reddy, Vice-Chairman, Aditya Educational Institutions, Surampalem, E. G. Dist., Andhra Pradesh (India) for providing necessary laboratory facilities to carry out the work.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

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  1. Aditya Institute of Pharmaceutical Sciences and Research, Surampalem, E.G. Dist., Andhra Pradesh, 533437, India

    Mithun Rudrapal & Mullapudi P. K. Sowmya

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  1. Mithun Rudrapal
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  2. Mullapudi P. K. Sowmya
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Correspondence to Mithun Rudrapal.

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Rudrapal, M., Sowmya, M.P.K. Design, Synthesis, Drug-Likeness Studies and Bio-Evaluation of Some New Chalconeimines. Pharm Chem J 53, 814–821 (2019). https://doi.org/10.1007/s11094-019-02084-y

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  • DOI: https://doi.org/10.1007/s11094-019-02084-y

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