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Solid State Fermentation Optimization of Pleurotus Ostreatus for Lovastatin Production

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Pharmaceutical Chemistry Journal Aims and scope

The present study was aimed at optimization of the solid state fermentation of lovastatin (HMG-CoA reductase inhibitor) using the Plackett – Burman (PB) design and response surface methodology (RSM) for edible and medicinal mushroom Pleurotus ostreatus so as to improve Pleurotus-fermented products (like red yeast rice) with health promoting properties. According to the results of PB design, the barley, yeast extract, and particle size of the solid substrate were found to have significant effect on lovastatin production. The concentrations of barley and yeast extract and the particle size of the solid substrate were further optimized by RSM. As a result, high lovastatin production (34.97 mg/g) was achieved at the optimized conditions of barley (8 g), yeast extract (1% w/w), and particle size of the solid substrate (0.5 - 1 mm) at 28°C for 6 days.

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Authors and Affiliations

  1. Eskişehir Osmangazi University, Graduate School of Natural and Applied Sciences, 26480, Eskişehir, Turkey

    Burcu Atlı

  2. Eskişehir Osmangazi University, Faculty of Science and Arts, Department of Biology, 26480, Eskişehir, Turkey

    Mustafa Yamaç

  3. Eskişehir Osmangazi University, Faculty of Science and Arts, Department of Statistics, 26480, Eskişehir, Turkey

    Zeki Yıldız

  4. Eskişehir Osmangazi University, Faculty of Engineering and Architecture, Department of Chemical Engineering, 26480, Eskişehir, Turkey

    Musa Şőlener

Authors
  1. Burcu Atlı
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  2. Mustafa Yamaç
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  3. Zeki Yıldız
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  4. Musa Şőlener
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Correspondence to Mustafa Yamaç.

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Atlı, B., Yamaç, M., Yıldız, Z. et al. Solid State Fermentation Optimization of Pleurotus Ostreatus for Lovastatin Production. Pharm Chem J 53, 858–864 (2019). https://doi.org/10.1007/s11094-019-02090-0

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  • DOI: https://doi.org/10.1007/s11094-019-02090-0

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