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Psychotropic medicine beliefs, side effects and adherence in schizophrenia: a patient–caregiver dyad perspective

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Abstract

Background Medication adherence is essential in the management of schizophrenia. Yet poor treatment uptake has negative consequences on patients and their primary caregivers. Objective To examine the association among beliefs about psychotropic medications, side effects and adherence from a patient-caregiver dyad perspective. Setting This study was conducted in a public psychiatric hospital setting in Accra, Ghana. Methods A cross-sectional study was conducted among 121 patient-caregiver dyads using an interviewer-administered data collection approach.Main outcome measure Beliefs about medicines, side-effects and medication adherence. Results The patient and caregiver-reported level of medication adherence was 28.1 %. Using the Kappa index, the level of agreement between the responses of patients and their caregivers ranged from slight to moderate. Both patients and caregivers rated necessity higher than concern (patients: 1.67 ± 0.84, caregiver: 1.79 ± 0.96). Significant positive relations between specific-necessity, necessity–concerns differential and medication adherence were recorded while specific–concern, general harm and side-effects correlated negatively with medication adherence from the dyad. The odds of adhering to medications increased by 58 and 64 % for each unit increase in specific-necessity and general overuse scores respectively. However, a unit increase in specific–concern score and high side-effects scores were associated with lower odds of adherence. Conclusions This study highlights the need for patient-caregiver collaborations in decision-making relating to medication adherence in schizophrenia. Thus, in clinical practice, there is the need to recognize that caregivers are essential partners, and patient-caregiver views about psychotropic medications are critical in enhancing adherence for positive mental health outcomes.

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The datasets used and analyzed in this study are available as supplementary material.

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Authors and Affiliations

  1. Department of Pharmacy Practice and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, University of Ghana, P. O. Box LG 43, Legon, Ghana

    Irene A. Kretchy & Emmanuel M. Kwarteng

  2. Department of Public Health, Falk College, Syracuse University, White Hall, 13244, Syracuse, NY, USA

    Bernard Appiah

  3. Department of Biostatistics, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG13, Legon, Ghana

    Kofi Agyabeng

  4. Department of Pharmacy, Accra Psychiatric Hospital, Accra, Ghana

    Enyonam Ganyaglo

  5. Department of Psychiatry, Korle Bu Teaching Hospital, Accra, Ghana

    Grace Owusu Aboagye

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  1. Irene A. Kretchy
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Correspondence to Irene A. Kretchy.

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Kretchy, I.A., Appiah, B., Agyabeng, K. et al. Psychotropic medicine beliefs, side effects and adherence in schizophrenia: a patient–caregiver dyad perspective. Int J Clin Pharm 43, 1370–1380 (2021). https://doi.org/10.1007/s11096-021-01264-9

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