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Predicting moderate improvement and decline in pediatric asthma quality of life over 24 months

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Abstract

Objective

To determine factors associated with 24-month change in quality of life in children with asthma and their parents during the Childhood Asthma Management Program (CAMP).

Methods

Participants from 4 CAMP clinical centers were administered the Pediatric Asthma Quality of Life questionnaire and protocol measures of asthma symptoms, lung function, and psychological measures.

Results

Multivariate logistic regression analyses determined predictors of moderate change in quality of life. Subclinical levels of depression predicted moderate improvement in child-reported quality of life. Level of depressed affect together with clinical asthma features predicted moderate decline. Improvement in parent quality of life was predicted by perception of illness burden, whereas family features and a child missing school predicted moderate decline.

Conclusions

This ancillary study provided an opportunity to examine the determinants of 24-month change in parent and child of quality of life within a subset of the CAMP participants. Moderate changes in quality of life occur in clinical studies and have both psychosocial correlates and illness characteristics.

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Acknowledgments

Supported by the Agency for Health Care Policy and Research (R03HS09123-01) and contract from the US Department of Health and Human Services, National Heart, Lung, and Blood Institute (NHLBI-HR-90-13). CAMP has been supported by contracts NO1-HR-16044, 16045, 16046, 16047, 16048, 16049, 16050, 16051, and 16052 from the National Heart Lung and Blood Institute. Additional support was received from the General Clinical Research Center at the University of New Mexico (NCRR-GCRC grant M01-RR00997) and National Jewish Medical and Research Center (NCRR-GCRC grant M01-RR00051).

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Authors and Affiliations

  1. Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

    Robert D. Annett

  2. Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA

    Bruce G. Bender

  3. Department of Family & Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

    Betty Skipper

  4. Department of Adolescent Medicine, Children’s Hospital and Research Center Oakland, Oakland, CA, USA

    Celeste Allen

Authors
  1. Robert D. Annett
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  2. Bruce G. Bender
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  3. Betty Skipper
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  4. Celeste Allen
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Correspondence to Robert D. Annett.

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Annett, R.D., Bender, B.G., Skipper, B. et al. Predicting moderate improvement and decline in pediatric asthma quality of life over 24 months. Qual Life Res 19, 1517–1527 (2010). https://doi.org/10.1007/s11136-010-9715-4

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